Publications

  • 2024

    • Bellstedt, M., Holtrup, A., Otto, N., Berndt, M., Scherff, A. D., Papan, C., Robitzsch, A., Missler, M., Darici D. (2024) Gaze cueing improves pattern recognition of histology learners; Anatomical sciences education 10.1002/ase.2498 [ Advance online publication ]; doi: 10.1002/ase.2498
    • Brockhaus J., Kahl I., Ahmad M., Repetto D., Reissner C., Missler M. (2024) Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx; Cells 13(11), 981; doi: 10.3390/cells13110981  -  [ epub ahead of print ]
    • Bostedt D., Dogan E.H., Benker S.C., Rasmus M.A., Eisner E., Simon N.L., Schmitz M., Missler M., Darici D. (2024) Interprofessional socialization of first-year medical and midwifery students: effects of an ultra-brief anatomy training; BMC Med Educ. 24:464; doi: 10.1186/s12909-024-05451-w  -  [ epub ahead of print ]
    • Otto N., Böckers A., Shiozawa T., Brunk I., Schumann S., Kugelmann D., Missler M., Darici D. (2024) Profiling learning strategies of medical students: A person-centered approach; Med Educ. 1-11; doi: 10.1111/medu.15388  -  [ epub ahead of print ]
    • Koumoundourou A., Rannap M., De Bruyckere E., Nestel S., Reissner C., Egorov A.V., Liu P., Missler M., Heimrich B., Draguhn A., Britsch S. (2024) Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway; eLife 12:RP89854; doi: 10.7554/eLife.89854
    • Mohrmann L., Seebach J., Missler M., Rohlmann A. (2024) Distinct Alterations in Dendritic Spine Morphology in the Absence of  β-Neurexins; Int. J. Mol. Sci. 25(2), 1285; doi: 10.3390/ijms25021285  -  [ epub ahead of print ]

  • 2023

    • Darici D., Flägel K., Sternecker K., Missler M. (2023) Transfer of learning in histology: Insights from a longitudinal study; Anat Sci Educ 17:274-286; doi: 10.1002/ase.2363
    • Darici D., Reissner C., Missler M. (2023) Webcam-based eye-tracking to measure visual expertise of medical students during online histology training; GMS J Med Educ 40(5):Doc60; doi: 10.3205/zma001642
    • Darici D., Masthoff M., Rischen R., Schmitz M., Ohlenburg H., Missler M. (2023) Medical imaging training with eye movement modeling examples: A randomized controlled study; Medical Teacher 45(8):918–924; doi: 10.1080/0142159X.2023.2189538
    • de Arce K.P., Ribic A., Chowdhury D., Watters K., Thompson G.J., Sanganahalli B.G., Lippard E.T.C., Rohlmann A., Strittmatter S.M., Missler M., Hyder F., Biederer T. (2023) Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions; Nat Commun 28;14(1):459; doi: 10.1038/s41467-023-36042-w
    • Darici D., Schneider A.Y.D., Missler M., Pfleiderer B. (2023) Are stereotypes in decline? The portrayal of female anatomy in e-learning; Anat Sci Educ. 16(4):720–732; doi: 10.1002/ase.2211

  • 2022

    • Ablinger C., Eibl C., Geisler S.M., Campiglio M., Stephens G.J., Missler M., Obermair G.J. (2022) α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions; Int. J. Mol. Sci. 23(17), 9885; doi: 10.3390/ijms23179885
    • Gass M.M., Borkowsky S., Lotz ML., Siwek R., Schröter R., Nedvetsky P., Luschnig S., Rohlmann A., Missler M., Krahn M.P. (2022) PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes; Cellular and Molecular Life Sciences 79:248; doi: 10.1007/s00018-022-04273-7
    • Darici D., Missler M., Schober A., Masthoff M., Schnittler H., Schmitz M. (2022) "Fun slipping into the doctor's role" - The relationship between sonoanatomy teaching and professional identity formation before and during the Covid-19 pandemic; Anat Sci Educ. 15(3):447–463; doi: 10.1002/ase.2178
    • Ferdos S., Brockhaus J., Missler M., Rohlmann A. (2022) Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons;Front. Neuroanat. 15:757017; doi: 10.3389/fnana.2021.757017

  • 2021

    • William N., Reissner C., Sargent R., Darlington T.M., DiBlasi E., Li Q.S., Keeshin B., Callor W.B., Ferris E., Jerominski L., Smith K.R., Christensen E.D., Gray D.M., Camp N.J., Missler M., Williams M.E., Coon H. (2021) Neurexin 1 variants as risk factors for suicide death;Mol Psychiatry; doi: 10.1038/s41380-021-01190-2
    • Klatt O., Repetto D., Brockhaus J., Reissner C., El Khallouqi A., Rohlmann A., Heine M., Missler M. (2021) Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior; Cell Rep. 35(11):109266; doi: 10.1016/j.celrep.2021.109266
    • Albert T.K., Interlandi M., Sill M., Graf M., Moreno N., Menck K., Rohlmann A., Melcher V., Korbanka S., Meyer Zu Hörste G., Lautwein T., Frühwald M.C., Krebs C.F., Holdhof D., Schoof M., Bleckmann A., Missler M., Dugas M., Schüller U., Jäger N., Pfister S.M., Kerl K. (2021) An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma; Neuro Oncol 23(4):586-598; doi: 10.1093/neuonc/noaa254
    • Schöpf C.L., Ablinger C., Geisler S.M., Stanika R.I., Campiglio M., Kaufmann W.A., Nimmervoll B., Schlick B., Brockhaus J., Missler M., Shigemoto R. and Obermair G.J. (2021) Presynaptic α2δ subunits are key organizers of glutamatergic synapses; PNAS 118(14):e1920827118; doi: 10.1073/pnas.1920827118
    • Darici D., Reissner C., Brockhaus J., Missler M. (2021) Implementation of a fully digital histology course in the anatomical teaching curriculum during COVID-19 pandemic; Ann Anat 236:151718; doi: 10.1016/j.aanat.2021.151718
    • Heiden S., Siwek R., Lotz M.L., Borkowsky S., Schröter R., Nedvetsky P., Rohlmann A., Missler M., Krahn M.P. (2021) Apical‑basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes; Cell Mol Life Sci 78(7):3657-3672; doi: 10.1007/s00018-021-03769-y

  • 2020

    • Pan Y. E., Tibbe D., Harms F. L., Reissner C., Becker K., Dingmann B., Mirzaa G., Kattentidt-Mouravieva A. A., Shoukier M., Aggarwal S., Missler M., Kutsche K., and Kreienkamp H. J. (2020) Missense mutations in CASK interfere with neurexin binding and neurexin-induced oligomerization; J. Neurochem 157(4):1331-1350; doi: 10.1111/jnc.15215
    • Muellerleile J., Blistein A., Rohlmann A., Scheiwe F., Missler M., Schwarzacher S.W., Jedlicka P. (2020) Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin; Sci Rep. 10:16058; doi: 10.1038/s41598-020-72925-4
    • Bikbaev A., Ciuraszkiewicz-Wojciech A., Heck J., Klatt O., Freund R., Mitlöhner J., Lacalle S.E., Sun M., Repetto D., Frischknecht R., Ablinger C., Rohlmann A., Missler M., Obermair G.J., Di Biase V., Heine M. (2020) Auxiliary a2d1 and a2d3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development; J Neurosci 40(25):4824-4841; doi: 10.1523/JNEUROSCI.1707-19.2020

  • 2019

    • Herich S., Schneider-Hohendorf T., Rohlmann A., Khaleghi Ghadiri M., Schulte-Mecklenbeck A., Zondler L., Janoschka C., Ostkamp P., Richter J., Breuer J., Dimitrov S., Rammensee H.G., Grauer O.M., Klotz L., Gross C.C., Stummer W., Missler M., Zarbock A., Vestweber D., Wiendl H., Schwab N. (2019) Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis; Brain 142(11):3411-3427; doi: 10.1093/brain/awz301
    • Lin A.Y., Henry S., Reissner C., Neupert C., Kenny C., Missler M., Beffert U., Ho A. (2019) A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function; Sci Rep. 9:6024; doi: 10.1038/s41598-019-42635-7
    • Brockhaus J., Brüggen B., Missler M. (2019) Imaging and analysis of presynaptic calcium influx in cultured neurons using synGCaMP6f; Front Synaptic Neurosci 11:12; doi: 10.3389/fnsyn.2019.00012
    • Geisler S., Schöpf C.L., Stanika R., Kalb M., Campiglio M, Repetto D, Traxler L, Missler M., Obermair G.J. (2019) Presynaptic α2δ-2 calcium channel subunits regulate postsynaptic GABAA-receptor abundance and axonal wiring; J Neurosci 39 (14) 2581-2605; doi: 10.1523/JNEUROSCI.2234-18.2019

  • 2018

    • Brockhaus J., Schreitmüller M., Repetto D., Klatt O., Reissner C., Elmslie K., Heine M., Missler M. (2018) α-Neurexins together with α2δ-1 auxiliary subunits regulate Ca2+ influx through CaV2.1 channels; J Neurosci 38(38):8277-8294; doi: 10.1523/JNEUROSCI.0511-18.2018
    • Repetto D., Brockhaus J., Rhee H.J., Lee C.K., Kilimann M.W., Rhee J. S., Northoff L.M., Guo W., Reissner C., Missler M. (2018) Molecular Dissection of Neurobeachin Function at Excitatory Synapses; Front Synaptic Neurosci 10:28; doi: 10.3389/fnsyn.2018.00028

  • 2017

    • Hallmann A.L., Araúzo-Bravo M.J., Mavrommatis L., Ehrlich M., Röpke A., Brockhaus J., Missler M., Sterneckert J., Schöler H.R., Kuhlmann T., Zaehres H., Hargus G. (2017) Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein; Sci Rep. 7:42991; doi: 10.1038/srep42991

  • 2016

    • Voigt A., Freund R., Heck J., Missler M., Obermair G.J., Thomas U., Heine M. (2016) Dynamic association of calcium channel subunits at the cellular membrane; Neurophotonics 3(4), 041809; doi: 10.1117/1.NPh.3.4.041809
    • Martinelli D.C., Chew K.S., Rohlmann A., Lum M.Y., Ressl S., Hattar S., Brunger A.T., Missler M., Südhof T.C. (2016) Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors; Neuron 91:1-18; doi: 10.1016/j.neuron.2016.07.002

  • 2015

    • Palm T., Bolognin S., Meiser J., Nickels S., Träger C., Meilenbrock R.L., Brockhaus J., Schreitmüller M., Missler M., Schwamborn J.C. (2015) Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia; Sci Rep. 5:16321; doi: 10.1038/srep16321
    • Neupert C., Schneider R., Klatt O., Reissner C., Repetto D., Biermann B., Niesmann K., Missler M. and Heine M. (2015) Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals; J Neurosci 35(40):13629-47; doi: 10.1523/JNEUROSCI.4041-14.2015
    • Lenders M., Hofschröer V., Schmitz B., Kasprzak B., Rohlmann A., Missler M., Pavenstädt H., Oberleithner H., Brand S.M., Kusche-Vihrog K., Brand E. (2015) Differential response to endothelial epithelial sodium channel inhibition ex vivo correlates with arterial stiffness in humans. J Hypertens 33(12):2455-62; doi:10.1097/HJH.0000000000000736
    • Shen Y., Ge W.P., Li Y., Hirano A., Lee H.Y., Rohlmann A., Missler M., Tsien R., Jan L.Y., Fu Y.H., Ptáček L.J. (2015) Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. PNAS 112(10):2935-2941; doi: 10.1073/pnas.1501364112
    • Born G., Grayton H.M., Langhorst H., Dudanova I., Rohlmann A., Woodward B., Collier D., Fernandes C. and Missler M. (2015). Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors. Front Synaptic Neurosci 7:3; doi: 10.3389/fnsyn.2015.00003
    • Blanque A., Repetto D., Rohlmann A., Brockhaus J., Duning K., Pavenstädt H., Wolff I. and Missler M. (2015) Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro. Front Neuroanat 9:13; doi: 10.3389/fnana.2015.00013

  • 2014

    • Reissner C., Stahn J., Breuer D., Klose M., Pohlentz G., Mormann M. and Missler M. (2014) Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain. J Biol Chem 289(40):27585-27603; doi:10.1074/jbc.M114.595413
    • Born G., Breuer D., Wang S., Rohlmann A., Coulon P., Vakili P., Reissner C., Kiefer F., Heine M., Pape H.C., Missler M. (2014) Modulation of synaptic function through the α-neurexin-specific ligand neurexophilin-1. PNAS 111(13):E1274–E1283; doi: 10.1073/pnas.1312112111
    • Repetto D., Camera P., Melani R., Morello N., Russo I., Calcagno E., Tomasoni R., Bianchi F., Berto G., Giustetto M., Berardi N., Pizzorusso T., Matteoli M., Di Stefano P., Missler M., Turco E., Di Cunto F. and Defilippi P. (2014) p140Cap Regulates Memory and Synaptic Plasticity through Src-Mediated and Citron-N-Mediated Actin Reorganization. J Neurosci. 34(4):1542-53; doi: 10.1523/JNEUROSCI.2341-13.2014
    • Biermann B., Sokoll S., Klueva J., Missler M., Wiegert J.S., Sibarita J.B., and Heine M. (2014) Imaging of molecular surface dynamics in brain slices using single-particle tracking. Nat Commun. 5:3024; doi: 10.1038/ncomms4024

  • 2013

    • Runkel F., Rohlmann A., Reissner C., Brand S.M. and Missler M. (2013) Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes. J Neurochem. 127(1):36-47; doi:10.1111/jnc.12372
    • Grayton H.M., Missler M., Collier D.A. and Fernandes C. (2013) Altered Social Behaviours in Neurexin 1a Knockout Mice Resemble Core Symptoms in Neurodevelopmental Disorders. PLoS ONE 8(6): e67114; doi: 10.1371/journal.pone.0067114
    • Duning K., Wennmann D.O., Bokemeyer A., Reissner C., Wersching H., Thomas C., Buschert J., Guske K., Franzke V., Floel A., Lohmann H., Knecht S., Brand S.M., Poter M., Rescher U., Missler M., Seelheim P., Propper C., Boeckers T.M., Makuch L., Huganir R., Weide T., Brand E., Pavenstadt H. and Kremerskothen J., (2013) Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance. Transl Psychiatry 3:e272; doi: 10.1038/tp.2013.49

  • 2012 und älter

    • Niesmann K., Breuer D., Brockhaus J., Born G., Wolff I., Reissner C., Kilimann M.W., Rohlmann A. and Missler M. (2011) Dendritic spine formation and synaptic function require neurobeachin; Nat. Commun. 2:557; doi: 10.1038/ncomms1565
    • Biermann B., Ivankova-Susankova K., Bradaia A., Aziz S.A., Besseyrias V., Kapfhammer J.P., Missler M., Gassmann M. and Bettler B. (2010) The Sushi Domains of GABAB Receptors Function as Axonal Targeting Signals. J Neuroscience 30(4):1385–1394; doi: 10.1523/JNEUROSCI.3172-09.2010
    • Medrihan, L., Rohlmann, A., Fairless, R., Andrae, J., Döring, M., Missler, M., Zhang, W. and Kilimann, M.W. (2009) Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses; J Physiol 587(21), 5095-5106; doi: 10.1113/jphysiol.2009.178236.
    • Reissner, C., Klose, M., Fairless, R. and Missler, M. (2008) Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components. PNAS 105(39), 15124-15129; doi: 10.1073/pnas.0801639105.
    • Fairless, R., Ahmad, M., Masius, H., Rohlmann, A., Heupel, K., Reissner, C., Dresbach, T. and Missler, M. (2008) Polarized targeting of neurexins to synapses is regulated by their c-terminal sequences. J Neuroscience 28(48): 12969-12981; doi: 10.1523/JNEUROSCI.5294-07.2008
    • Medrihan, L., Tantalaki, E., Aramuni, G., Sargsyan, V., Dudanova, I., Missler, M. and Zhang, W. (2008) Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. J Neurophysiol 99(1), 112-121
    • Dudanova, I., Tabuchi, T., Rohlmann, A., Südhof, T.C., and Missler, M. (2007) Deletion of α-neurexins does not cause a major impairment of axonal pathfinding or pynapse formation. J Comp Neurol 502, 261-274.
    • Atasoy, D., Schoch, S., Ho, A., Nadasy, K.A., Liu, X., Zhang, W., Mukherjee, K., Nosyreva, E.D., Fernandez-Chacon, R., Missler, M., Kavalali, E.T., and Südhof, T.C. (2007) Deletion of CASK is lethal and impairs synaptic function. PNAS 104, 2525-2530.
    • Varoqueaux, F., Aramuni, G., Rawson, R., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T.C., and Brose, N. (2006) Neuroligins determine synapse maturation and function. Neuron 51, 741-754.
    • Dudanova, I., Sedej, S., Ahmad, M., Masius, H., Sargsyan, V., Zhang, W., Riedel, D., Angenstein, F., Schild, D., Rupnik, M., and Missler, M. (2006) Important contribution of α−neurexins to Ca2+ -triggered release of secretory granules. J Neurosci 26, 10599-10613.  
    • Sons, M.S., Busche, N., Strenske, N., Moser, T., Ernsberger, U., Mooren, F.C., Zhang, W., Ahmad, M., Steffens, H., Schomburg, E.D., Plomp, J.J., and Missler, M. (2006) α−Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction. Neurosci 138, 433-446.
    • Beglopoulos, V., Montag-Sallaz, M., Rohlmann, A., Piechotta, K., Ahmad, M., Montag, D., and Missler, M. (2005) Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol 25, 7278-7288.
    • Zhang, W., Rohlmann, A., Sargsyan, V., Aramuni, G., Hammer, R.E., Südhof, T.C., and Missler, M. (2005) Extracellular domains of α-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ -channels. J Neurosci 25:4330-4342.
    • Kattenstroth, G., Tantalaki, E., Südhof, T.C., Gottmann, K., and Missler, M. (2004) Postsynaptic N-methyl-D-aspartate receptor function requires α−neurexins. PNAS 101, 2607-2612.  
    • Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R.E., Gottmann, K., and Südhof, T.C. (2003) α−Neurexins couple Ca2+ -channels to synaptic vesicle exocytosis. Nature 423, 939-948 . (MM ist auch „corresponding author“)
    • Safavi-Abbasi, S., Wolff, J.R., and Missler, M. (2001) Rapid morphological changes in astrocytes are accompanied by re-distribution but not quantitative changes of cytoskeletal proteins. Glia  36, 102-115.
    • Verhage, M., Maia, A.S., Plomp, J.J., Brussard, A.B., Heeroma, J.H., Vermeer, H., Toonen, R., Hammer, R.E., van den Berg, T., Missler, M., Geuze, H.J., and Südhof, T.C. (2000) Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science 287, 864-869.