Translationale molekulare und optische Bildgebung in Gliomen: Spektroskopie, maschinelles Lernen und Validierung mittels Massenspektrometrie.

Collaboration with J. Abiola (DAAD fellow) from the University of Ibadan, Nigeria

König S, Marco H, Gäde G (2022) The proline effect and the tryptophane immonium ion assist in de novo sequencing of adipokinetic hormones. submitted

Download: AKH_DBv1_15112022.xlsx

A highly interdisciplinary program among the Faculties of Biology, Chemistry, Pharmacy, and Medicine to strengthen cutting-edge research on natural products.

Start March 2022

Graduate School of Natural Products

Aziz S, König S, Umer M, Akhter TS, Iqbal S, Ibrar M, Ur-Rehman T, Ahmad T, Hanafiah A, Zahra R, Rasheed F. (2023) Risk factor profiles for gastric cancer prediction with respect to Helicobacter pylori: A study of a tertiary care hospital in Pakistan. Artif Intell Gastroenterol 4(1), dx.doi.org/10.35712/aig.v4.i1.0000

GUI executable file archive, Vs. 06 for Windows 10:

Gastric_Cancer_GUI_Executable_File_version_06.part1.rar
Gastric_Cancer_GUI_Executable_File_version_06.part2.rar
Gastric_Cancer_GUI_Executable_File_version_06.part3.rar

(unpack, e.g. with 7-Zip or WinRAR, and then run ML_Model_Gastric_cancer.exe)

Scholarship for S. Aziz from the Higher Education Commission of Pakistan (2021-2022)

Aziz S, Rasheed F, Zahra R, König S. (2022) Gastric cancer pre-stage detection and early diagnosis of gastritis using serum protein signatures. Molecules 27:2857

Aziz S, König S, Noor H, Nadeem M, Zahra R, Rasheed F (2022) Isolated dextrogastria with eventration of right hemidiaphragm and hiatal hernia in an adult male. BMC Gastroenterology 22:56

Aziz S, Rasheed F, Akhter TS, Zahra R, König S (2022) Microbial proteins in stomach biopsies associated with gastritis, ulcer, and gastric cancer. Molecules 27: 5410, doi: 10.3390/molecules27175410

Aziz S, Rasheed F, Zahra R, König S (2023) Mass spectrometry-based proteomics of minor species in the bulk: Questions to raise with respect to the untargeted analysis of viral proteins in human tissue. Life 13, 544, doi: 10.3390/life13020544

Die Core Unit arbeitet gemeinsam mit Prof. Sandra Kraljevic Pavelic vom Institut für Biotechnologie an einem Projekt zur Proteinanalyse von Istrischen Rohschinken. (2019)

Determination of protoporphyrin IX in blood of glioblastoma patients

A. Walke, E. Suero Molina, W. Stummer, S. König. “Protoporphyrin IX analysis from blood and serum in the context of neurosurgery of glioblastoma.” In: Mass Spectrometry, Ed. G. Mitulovic, IntechOpen, London, 2020, doi.org/10.5772/intechopen.95042

Black D, Kaneko S, Walke A, König S, Stummer W, Suero Molina E. (2021) Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery. Sci Rep 11, 20009

Walke A, König S. (2021) Protorphyrin IX purification from blood and serum for mass analysis – considerations with respect to neurosurgery. RCM, DOI:10.1002/rcm.9138

Walke A, Black D, Valdes PA, Stummer W, König S, Suero-Molina E (2023) Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements. Scientific Reports 13: 3829, doi.org/10.1038/s41598-023-30680-2

Suero Molina E, Black D, Walke A, Azemi G, d’Alessandro F, König S, Stummer W (2023) Unraveling the blue shift in porphyrin fluorescence in glioma: The 620 nm peak and its potential significance in tumor biology. Frontiers in Neuroscience 17:1261679, doi: 10.3389/fnins.2023.1261679

Walke A, Krone C, Stummer W, König S+, Suero-Molina E+ (2024) Protoporphyrin IX in serum of high-grade glioma patients: A novel target for disease monitoring via liquid biopsy. Sci Rep 14: 4297, doi.org/10.1038/s41598-024-54478-y

The Core Unit collaborates with Prof. Zanda Daneberga of the Institute for Oncology on the project "Prolonged hypoxia induced differential protein signatures in BRCA1 +/- triple negative breast cancer cell lines", funded by the Baltic-German University Liaison Office. (2019)

The complex-regional pain syndrome (CRPS) is a neurological-orthopedic-traumatologic pain disease, which develops in approximately 5% of patients for instance after bone fracture. These patients observe, e.g., overheating in the respective limbs, edema, excessive sweating and pain during movement
The aim of the projectes of the physician from Mainz, Frank Birklein, and the chemist / bioanalytician from Münster Simone König is to investigate the inflammatory processes in tissue such as skin and assign them to clinical symptoms in order to prepare for targeted therapy of CRPS.
News Medical Faculty
Juraforum

Funding of DFG and DAAD allows the collaboration with Prof. M. Krishnan of Bharathidasan University, Tiruchirappalli, India, for the investigation of different silkworm proteins.
News Medical Faculty
IDW