Circular chromosome conformation capture combined with high-throughput sequencing (4C-seq) identifies chromosomal interactions between one predefined interaction partner and virtually any other part of the genome. Since 4C-seq data sets are complex in nature and prone to bias, special care has to be taken to achieve reliable results.

In cooperation with the Institute of Molecular Tumor Biology of the University of Münster, we explore both 4C-seq data sets and test available algorithms regarding their performance on different interaction structures. We are also interested in improving resulting visualizations and downstream analyses.

Contact: Dr. Carolin Walter