The function and dysfunction of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels in the thalamocortical system is investigated using new specific drugs.
Budde. T
Whole-cell patch clamp recording showing the current reduction in a thalamocortical (TC) neuron in a brain slices by 10 µM of the HCN4-selective blocker EC18. The current carried by HCN channels (Ih) in the presence (red line) and absence (black line) of the drug was elicited by a hyperpolarizing voltage step.