Curriculum Vitae

2020-today       PhD student at AG Ludwig, Institute of Molecular Virology, University Münster

                        CiM-IMPRS Graduate Program (associated member)

2017-2019         Master of Science in Molecular Biomedicine, University Münster

2014-2017         Bachelor of Science in Life Sciences, University Osnabrück

Project

Immune response and systemic replication during infections with highly pathogenic Influenza A viruses regarding the emergence of cytokine storms and systemic infection in mice. Investigation of three pre-clinically tested MAPK p38 inhibitors as potential treatment for severe influenza as well as for severe COVID-19 in Calu-3 cells, in a human lung model and in mice.

Methods

Cell culture, human lung model, mouse model, infection, influenza viruses, SARS-CoV-2, BSL-2, BSL-3, inhibitor treatment, drug studies, Western blot, quantitative RT-PCR analysis, Plaque assay, transcriptomics, flow cytometry

Publications and awards

Schreiber, A., Viemann, D., Schoning, J., Schloer, S., Mecate Zambrano, A., Brunotte, L., Faist, A., Schofbanker, M., Hrincius, E., Hoffmann, H., Hoffmann, M., Pohlmann, S., Rescher, U., Planz, O., and Ludwig, S. (2022) The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses, Cell Mol Life Sci 79, 65.

Kumar, S., Çalışkan, D. M., Janowski, J., Faist, A., Conrad, B. C. G., Lange, J., Ludwig, S., and Brunotte, L. (2021) Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics, Front Immunol 12, 752227.

Third place Poster award, International Symposium on Zoonoses Research 2020