July 5th, 2024:

Visualizing the complex inner lives of macrophages.
Outstanding new study in Nature Cell Biology from the team of Dr Angelika Rambold, who will join our institute as independent group in early 2025. With “OrgaPlexing”, her team developed a novel multiplex imaging method that simultaneously illuminates several key organelle systems (mitochondria, endoplasmic reticulum, Golgi, peroxisomes, lipid bodies, lysosomes) in primary immune cells. Using this method to comprehensively map intracellular compartments, Angelika’s group identifies functional multiorganelle units (MOUs) that control intracellular cell metabolism and the production of inflammatory molecules in macrophages.
With great help from Frauke, Klaus and Manuel from IMB.

Link: https://www.nature.com/articles/s41556-024-01457-0