RESEARCH PAPERS

1. Holzinger, D., K. Fassl, W. de Jager, P. Lohse, U. F. Röhrig, M. Gattorno, A. Omenetti, S. Chiesa, F. Schena, J. Austermann, T. Vogl, D. B. Kuhns, S. M. Holland, C. Rodríguez-Gallego, R. López-Almaraz, J. I. Arostegui, E. Colino, R. Roldan, S. Fessatou, B. Isidor, S. Poignant, K. Ito, H.-J. Epple, J. A. Bernstein, M. Jeng, J. Frankovich, G. Lionetti, J. A. Church, P. Y. Ong, M. LaPlant, M. Abinun, R. Skinner, V. Bigley, U. S. Sachs, C. Hinze, E. Hoppenreijs, J. Ehrchen, D. Foell, J. J. Chae, A. Ombrello, I. Aksentijevich, C. Sunderkoetter, and J. Roth: "Single amino acid charge switch defines clinically distinct PSTPIP1 associated inflammatory diseases."
   J. Allergy Clin. Immunol. 136; 1337-45 (2015).
   
   
2. Vogl, T., M. Eisenblätter, T. Völler, S. Zenker, S. Hermann, P. van Lent, A. Faust, C. Geyer, B. Petersen, K. Roebrock, M. Schäfers, C. Bremer, J. Roth: "Alarmin S100A8/S100A9 as a biomarker of local inflammatory activity."
   Nature Commun. 5; 4593 (2014).
   
   
3. Qin, H., B. Lerman, I. Sakamaki, G. Wei, S. Cha, S. S. Rao, J. Qian, Y. Hailemichael, R. Nurieva, K. C. Dwyer, J. Roth, Q. Yi, W. W. Overwijk and L. W. Kwak: "Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice."
   Nature Med. 20; 676-681 (2014).
   
4. Austermann, J., J. Friesenhagen, S. K, Fassl, T, Ortkras, J. Burgmann, K. Barczyk-Kahlert, E. Faist, S. Zedler, S. Pirr, C. Rohde, C. Müller-Tidow, M. von Köckritz-Blickwede, C. S. von Kaisenberg, S. Flohé, T. Ulas, J. L. Schultze, J. Roth, T. Vogl, and D. Viemann: "Alarmins MRP8 and MRP14 induce stress-tolerance in phagocytes under sterile inflammatory conditions."
   Cell Rep. 9; 2112-2123 (2014).
   
   
5. Petersen, B., M. Wolf, J. Austermann, P. L. E. M. van Lent, D. Foell, M. Ahlmann, V. Kupas, K. Loser, C. Sorg, J. Roth, and T. Vogl: "The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis."
   EMBO-J. 32; 100-111 (2013).
   
   
6. Loser, K., T. Vogl, M. Voskort, A. Lüken, V. Kupas, L. Klenner, W. Nacken, L. Klenner, A. Kuhn, D. Föll, L. Sorokin, T. A. Luger, J. Roth, and Stefan Beissert: "The toll-like receptor 4 ligands Mrp8 and Mrp14 play a critical role in the development of autoreactive TCD8⁺ cells."
   Nat. Med. 6, 713-717 (2010).
   
   
7. Foell, D., N. Wulffraat, L. Wedderburn, H. Wittkowski, M. Frosch, J. Gerß, V. Stanevicha, D. Mihaylova, V. Ferriani, F. Kanakoudi Tsakalidou, I. Foeldvari, R. Cuttica, B. Gonzalez, A. Ravelli, R. Khubchandani, S. Oliveira, W. Armbrust, S. Garay, J. Vojinovic, X. Norambuena, M. Luz Gamir, J. Garcia Consuegra, L. Lepore, G. Susic, F. Corona, P. Dolezalova, A. Pistorio, A. Martini, N. Ruperto, and J. Roth: "Methotrexate withdrawal at 6 vs 12-months in juvenile idiopathic arthritis in remission: a randomized clinical trial."
   JAMA 303, 1266-1273 (2010).
   
   
8. Schmidt, M., B. Raghavan, V. Müller, T. Vogl, G. Feijer, S. Keck, C. Kalis, P. Nielsen, C. Galanos, J. Roth, A. Skerra, S. F. Martin, M. Freudenberg, and M. Goebeler: "A crucial role for hTLR4 in the development of contact allergy to nickel."
   Nat. Immunol. 11, 814-819 (2010).
   
   
9. Frosch, M., M. Ahlmann, T. Vogl, H. Wittkowski, N. Wulffraat, D. Foell, and J. Roth: "MRP8/MRP14, novel ligands of TLR4, and interleukin-1b form a positive feedback mechanism in systemic onset juvenile idiopathic arthritis."
   Arthritis Rheum. 60, 883-891 (2009).
   
   
10. Cheng, P., C. A. Corzo, N. Luetteke, B. Yu, S. Nagaraj, M. M. Bui, W. Nacken, C. Sorg, T. Vogl, J. Roth, and D. I. Gabrilovich: "Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein".
    J. Exp. Med. 205, 2235-2249 (2008).
    
    
11. Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, Torres VJ, Anderson KL, Dattilo BM, Dunman PM, Gerads R, Caprioli RM, Nacken W, Chazin WJ, Skaar EP: Metal chelation and inhibition of bacterial growth in tissue abscesses.
    Science. 319, 962-965 (2008).
    
    
12. Vogl, T., K. Tenbrock, S. Ludwig, N. Leukert, C. Ehrhardt, M. A. D. van Zoelen, W. Nacken, D. Foell, T. van der Poll, C. Sorg, and J. Roth: "MRP8 and MRP14 are novel endogenous activators of toll-like receptor 4 promoting lethal endotoxin-induced shock."
    Nature Med. 13, 1042-1049 (2007).
    
    
13. Ehrchen, J., L. Steinmüller, K. Barczyk, K. Tenbrock, W. Nacken, M. Eisenacher, U. Nordhues, C. Sorg, C. Sunderkötter, and J. Roth: "Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes."
    Blood 109, 1265-1274 (2007).
    
    
14. Foell, D., F. Ichida, T. Vogl, R. Chen, T. Miyawaki, C. Sorg, and J. Roth:
    "S100A12 (EN-RAGE): A novel serum marker in the monitoring of Kawasaki disease."
    Lancet 361, 1270-1272 (2003).
    
    
15. Sampson B., P. Richmond, C. Sunderkötter, B. E. Golden, J. H. Beattie, M. K. Fagerhol, N. Klein, I. Z. Kovar, B. Wolska-Kusnierz, and J. Roth: "Hyperzincaemia with hypercalprotectinaemia: a new disorder of zinc metabolism. Identification of calprotectin (S100A8/S100A9) as the zinc binding protein in patients with hyperzincaemia."
    Lancet 360, 1742-1745 (2002).
    
    
16. Rammes, A., J. Roth, M. Goebeler, M. Klempt, M. Hartmann, and C. Sorg: "MRP8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway."
    J. Biol. Chem. 272, 9496-9502 (1997).

REVIEWS

1. Chan, J. K., J. Roth, J. J. Oppenheim, K. J. Tracey, T. Vogl, M. Feldmann, N. Horwood, and J. Nanchahal: "Alarmins: Awaiting a clinical response."
   J. Clin. Invest. 122, 2711-2719 (2012)
   
   
2. Ehrchen, J. M., C. Sunderkötter, D. Foell, T. Vogl , and J. Roth^{:
   "}The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer."
   J. Leuko. Biol. 86, 557-566. (2009).
   
   
3. Frosch, M., and J. Roth: "New insights in systemic juvenile idiopathic arthritis: from pathophysiology to treatment." Rheumatology 47, 121-125 (2008).