Stephan J. Reshkin leads WP1.The project “An EGFR-based therapy targeting the NHERF1-EGFR-NHE1 axis” will elucidate the roles of the Na+/H+ exchanger NHE1, its scaffolding protein, NHERF1, in regulating epidermal growth factor receptor EGFR and therapy directed at the EGFR during PDAC progression. It is the ultimate goal to design a therapy targeting components of the “EGFR-axis” based on findings of this project.