Publikationen

  • 2021

    1. Neumann, Joachim; Binter, Maximilian Benedikt; Fehse, Charlotte; Marušáková, Margaréta; Büxel, Maren Luise; Kirchhefer, Uwe et al. (2021): Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria. In: Naunyn-Schmiedeberg's archives of pharmacology. DOI: 10.1007/s00210-021-02065-7.

  • 2020

    1. Boknik, P.; Eskandar, J.; Hofmann, B.; Zimmermann, N.; Neumann, J.; Gergs, U. (2020): Role of Cardiac A2A Receptors Under Normal and Pathophysiological Conditions. In: Frontiers in pharmacology 11, S. 627838. DOI: 10.3389/fphar.2020.627838.
    2. Bollmann, Paula; Werner, Franziska; Jaron, Marko; Bruns, Tom A.; Wache, Hartmut; Runte, Jochen et al. (2020): Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C. In: Frontiers in pharmacology 11, S. 591773. DOI: 10.3389/fphar.2020.591773.
    3. Gergs, Ulrich; Kirchhefer, Uwe; Bergmann, Fabian; Künstler, Bernhard; Mißlinger, Natascha; Au, Bastian et al. (2020): Characterization of Stressed Transgenic Mice Overexpressing H2-Histamine Receptors in the Heart. In: The Journal of pharmacology and experimental therapeutics 374 (3), S. 479–488. DOI: 10.1124/jpet.120.000063.
    4. Heinick, Alexander; Pluteanu, Florentina; Hermes, Christina; Klemme, Andre; Domnik, Manuel; Husser, Xenia et al. (2020): Annexin A4 N-terminal peptide inhibits adenylyl cyclase 5 and limits ß-adrenoceptor-mediated prolongation of cardiac action potential. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology. DOI: 10.1096/fj.201902094RR.
    5. Peischard, Stefan; Ho, Huyen Tran; Piccini, Ilaria; Strutz-Seebohm, Nathalie; Röpke, Albrecht; Liashkovich, Ivan et al. (2020): The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease. In: Scientific reports 10 (1), S. 16804. DOI: 10.1038/s41598-020-72966-9.
    6. Pluteanu, Florentina; Seidl, Matthias D.; Hamer, Sabine; Scholz, Beatrix; Müller, Frank U. (2020): Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM-IbΔC-X. In: Journal of the American Heart Association 9 (23), e016144. DOI: 10.1161/JAHA.119.016144.
    7. Seidl, Matthias D.; Fels, Benedikt; Kranick, Daniel; Sternberg, Alexandra; Grimm, Kristina; Stümpel, Frank T. et al. (2020): Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology. DOI: 10.1096/fj.201902301RR.

  • 2019

    1. Bögeholz, Nils; Pauls, Paul; Bauer, Bastian K.; Schulte, Jan S.; Frommeyer, Gerrit; Dechering, Dirk G. et al. (2019): Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy. In Fundam Clin Pharmacol. 33 (1), pp. 43–51. DOI: 10.1111/fcp.12404.
    2. Boknik, Peter; Drzewiecki, Katharina; Eskandar, John; Gergs, Ulrich; Hofmann, Britt; Treede, Hendrik et al. (2019): Evidence for Arrhythmogenic Effects of A2A-Adenosine Receptors. In Front Pharmacol. 10, p. 1051. DOI: 10.3389/fphar.2019.01051.
    3. Gergs, U.; Bernhardt, G.; Buchwalow, I. B.; Edler, H.; Fröba, J.; Keller, M. et al. (2019): Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors. In J Pharmacol Exp Ther. 369 (1), pp. 129–141. DOI: 10.1124/jpet.118.255711.
    4. Horsthemke, M.; Nutter, L. M.J.; Bachg, A. C.; Skryabin, B. V.; Honnert, U.; Zobel, T. et al. (2019): A novel isoform of myosin 18A (Myo18A?) is an essential sarcomeric protein in mouse heart. In J Biol Chem. 294 (18), pp. 7202–7218. Available online at PM:30737279; ISI:000468402900010.
    5. Puhl, S. L.; Weeks, K. L.; Güran, A.; Ranieri, A.; Boknik, P.; Kirchhefer, U. et al. (2019): Role of type 2A phosphatase regulatory subunit B56? in regulating cardiac responses to ?-adrenergic stimulation in vivo. In Cardiovasc Res. 115 (3), pp. 519–529. Available online at PM:30203051; ISI:000462707600013.
    6. Scholz, B.; Schulte, J. S.; Hamer, S.; Himmler, K.; Pluteanu, F.; Seidl, M. D. et al. (2019): HDAC (Histone Deacetylase) Inhibitor Valproic Acid Attenuates Atrial Remodeling and Delays the Onset of Atrial Fibrillation in Mice. In Circ Arrhythm Electrophysiol. 12 (3), e007071. Available online at PM:30879335; ISI:000469355000009.

  • 2018

    1. Bögeholz, Nils; Pauls, Paul; Dechering, Dirk G.; Frommeyer, Gerrit; Goldhaber, Joshua I.; Pott, Christian et al. (2018): Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia. In Front Pharmacol. 9, p. 933. DOI: 10.3389/fphar.2018.00933.

    2. Boknik, Peter; Drzewiecki, Katharina; Eskandar, John; Gergs, Ulrich; Grote-Wessels, Stephanie; Fabritz, Larissa et al. (2018): Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors. In Front Pharmacol. 9, p. 13. DOI: 10.3389/fphar.2018.00013.

    3. Bukowska, A.; Felgendreher, M.; Scholz, B.; Wolke, C.; Schulte, J. S.; Fehrmann, E. et al. (2018): CREM-transgene mice: An animal model of atrial fibrillation and thrombogenesis. In Thromb Res. 163, pp. 172–179. Available online at PM:28807377; ISI:000428772100027.
    4. Glaser, D.; Pluteanu, F.; Heinick, A.; Mueller, F. U.; Boknik, P.; Kirchhefer, U. (2018): Deletion of b56-alpha, a regulatory subunit of protein phosphatase 2a, is associated with an increased propensity to arrhythmia. In Eur Heart J. 39 1, p. 1208. Available online at ISI:000459824003800.
    5. Kirchhefer, U.; Hammer, E.; Heinick, A.; Herpertz, T.; Isensee, G.; Müller, F. U. et al. (2018): Chronic ?-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1. In J Mol Cell Cardiol. 125, pp. 195–204. Available online at PM:30389400; ISI:000453629400019.
    6. Krause, Thorsten; Grote-Wessels, Stefanie; Balzer, Felix; Boknik, Peter; Gergs, Ulrich; Kirchhefer, Uwe et al. (2018): Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells. In Naunyn Schmiedebergs Arch Pharmacol. 391 (8), pp. 859–873. DOI: 10.1007/s00210-018-1515-3.
    7. Kronenbitter, A.; Funk, F.; Hackert, K.; Gorreßen, S.; Glaser, D.; Boknik, P. et al. (2018): Corrigendum to 'Impaired Ca cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction' [J. Mol. Cell. Cardiol. 119 (2018) 28-39]. In J Mol Cell Cardiol. 121, p. 304. Available online at PM:29907408; ISI:000443763300033.
    8. Kronenbitter, A.; Funk, F.; Hackert, K.; Gorreßen, S.; Glaser, D.; Boknik, P. et al. (2018): Impaired Ca cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction. In J Mol Cell Cardiol. 119, pp. 28–39. Available online at PM:29674140; ISI:000435530200004.

    9. Krysiak, Judith; Unger, Andreas; Beckendorf, Lisa; Hamdani, Nazha; Frieling-Salewsky, Marion von; Redfield, Margaret M. et al. (2018): Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. In Nat Commun. 9 (1), p. 262. DOI: 10.1038/s41467-017-02483-3.

    10. Neumann, J.; Gergs, U.; Fabritz, L.; Kirdhhof, P.; Treede, H.; Hofmann, B.; Boknik, P. (2018): FURTHER STUDIES ON THE CARDIAC RELEVANCE OF HUMAN A2A ADENOSINE RECEPTORS. In Purinergic Signal. 14 1, S110-S110. Available online at ISI:000456281300275.
    11. Pluteanu, F.; Nikonova, Y.; Holzapfel, A.; Herzog, B.; Scherer, A.; Preisenberger, J. et al. (2018): Progressive impairment of atrial myocyte function during left ventricular hypertrophy and heart failure. In J Mol Cell Cardiol. 114, pp. 253–263. Available online at PM:29191788; ISI:000425839900025.
    12. Stümpel, Frank T.; Stein, Juliane; Himmler, Kirsten; Scholz, Beatrix; Seidl, Matthias D.; Skryabin, Boris V.; Müller, Frank U. (2018): Homozygous CREM-Ib?C-X Overexpressing Mice Are a Reliable and Effective Disease Model for Atrial Fibrillation. In Front Pharmacol. 9, p. 706. DOI: 10.3389/fphar.2018.00706.

    13. Wiedmann, Felix; Schulte, Jan S.; Gomes, Bruna; Zafeiriou, Maria-Patapia; Ratte, Antonius; Rathjens, Franziska et al. (2018): Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1. In Basic Res Cardiol. 113 (4), p. 27. DOI: 10.1007/s00395-018-0687-9.

    14. Yao, C.; Veleva, T.; Scott, L.; Cao, S.; Li, L.; Chen, G. et al. (2018): Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. In Circulation. 138 (20), pp. 2227–2242. Available online at PM:29802206; ISI:000452171400010.

  • 2017

    1. Bögeholz, N.; Schulte, J. S.; Kaese, S.; Bauer, B. K.; Pauls, P.; Dechering, D. G. et al. (2017): The Effects of SEA0400 on CaTransient Amplitude and Proarrhythmia Depend on the Na/CaExchanger Expression Level in Murine Models. In Front Pharmacol. 8, p. 649. Available online at PM:28983248; ISI:000411730300001.
    2. Gergs, U.; Fahrion, C. M.; Bock, P.; Fischer, M.; Wache, H.; Hauptmann, S. et al. (2017): Evidence for a functional role of calsequestrin 2 in mouse atrium. In Acta Physiol (Oxf). 219 (3), pp. 669–682. Available online at PM:27484853; ISI:000393941300013.
    3. Piccini, I.; Fehrmann, E.; Frank, S.; Müller, F. U.; Greber, B.; Seebohm, G. (2017): Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast K7.1 Recycling. In Front Physiol. 8, p. 705. Available online at PM:28959214; ISI:000410763300001.
    4. Pluteanu, C. F.; Scholz, B.; Schulte, J. S.; Muller, F. U. (2017): Sodium Valproate Reverses Electrical Remodeling of Atrial Myocytes Isolated from CREM-Ib Delta DC-X Transgenic Mice. In Biophys J. 112 1 (3), 545A-545A. Available online at ISI:000402375700718.
    5. Schmidt, C.; Wiedmann, F.; Kallenberger, S. M.; Ratte, A.; Schulte, J. S.; Scholz, B. et al. (2017): Stretch-activated two-pore-domain (K) potassium channels in the heart: Focus on atrial fibrillation and heart failure. In Prog Biophys Mol Biol. 130 (Pt B), pp. 233–243. Available online at PM:28526353; ISI:000423003000012.
    6. Seidl, M. D.; Stein, J.; Hamer, S.; Pluteanu, F.; Scholz, B.; Wardelmann, E. et al. (2017): Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-Ib?C-X Mice. In Circ Arrhythm Electrophysiol. 10 (8). Available online at PM:28784605; ISI:000407553700003.

  • 2016

    1. Bögeholz, N.; Pauls, P.; Kaese, S.; Schulte, J. S.; Lemoine, M. D.; Dechering, D. G. et al. (2016): Triggered activity in atrial myocytes is influenced by Na(+)/Ca(2+) exchanger activity in genetically altered mice. In J Mol Cell Cardiol. 101, pp. 106–115. Available online at PM:27838371; ISI:000391909800013.
    2. Bukowska, A.; Nikonova, Y.; Pluteanu, F.; Kockskaemper, J.; Chilukoti, R. K.; Wolke, C. et al. (2016): Anti-inflammatory effects of endothelin receptor blockade in the atrial tissue of spontaneously hypertensive rats. In Cardiovasc Res. 111 1, S20-S21. Available online at ISI:000379812500061.
    3. Keul, P.; van Borren, M. M.; Ghanem, A.; Müller, F. U.; Baartscheer, A.; Verkerk, A. O. et al. (2016): Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. In J Am Heart Assoc. 5 (5). Available online at PM:27207969; ISI:000386711200048.
    4. Krysiak, J.; Unger, A.; Hamdani, N.; Boknik, P.; Linke, W. A. (2016): A Novel Role for PP5 in Regulating Titin Phosphorylation and Function in the Heart. In Biophys J. 110 1 (3), 298A-298A. Available online at ISI:000375141600445.
    5. Mederle, K.; Gess, B.; Pluteanu, F.; Plackic, J.; Tiefenbach, K. J.; Grill, A. et al. (2016): The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a. In Cardiovasc Res. 110 (3), pp. 359–370. Available online at PM:27015675; ISI:000378442700011.
    6. Munchen, S.; Pieper, S.; Kirchhefer, U.; Muller, C.; Moskovits, J.; Lehrnbecher, T. et al. (2016): Voriconazole plasma concentrations and dosing in pediatric patients < 24 months. In Mycoses. 59 2, p. 35. Available online at ISI:000384013500071.
    7. Pla?ki, J.; Preissl, S.; Nikonova, Y.; Pluteanu, F.; Hein, L.; Kockskämper, J. (2016): Enhanced nucleoplasmic Ca(2+) signaling in ventricular myocytes from young hypertensive rats. In J Mol Cell Cardiol. 101, pp. 58–68. Available online at PM:27816525; ISI:000391909800008.
    8. Schulte, J. S.; Fehrmann, E.; Tekook, M. A.; Kranick, D.; Fels, B.; Li, N. et al. (2016): Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. In Basic Res Cardiol. 111 (2), p. 15. Available online at PM:26818679; ISI:000372265000006.

  • 2015

    1. Bögeholz, N.; Pauls, P.; Bauer, B. K.; Schulte, J. S.; Dechering, D. G.; Frommeyer, G. et al. (2015): Suppression of Early and Late Afterdepolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model. In Circ Arrhythm Electrophysiol. 8 (5), pp. 1210–1218. Available online at PM:26338832; ISI:000363374100031.
    2. Heinick, A.; Husser, X.; Himmler, K.; Kirchhefer, U.; Nunes, F.; Schulte, J. S. et al. (2015): Annexin A4 is a novel direct regulator of adenylyl cyclase type 5. In FASEB J. 29 (9), pp. 3773–3787. Available online at PM:26023182; ISI:000359915600015.
    3. Hoehn, M.; Zhang, Y.; Xu, J.; Gergs, U.; Boknik, P.; Werdan, K. et al. (2015): Overexpression of protein phosphatase 2A in a murine model of chronic myocardial infarction leads to increased adverse remodeling but restores the regulation of ?-catenin by glycogen synthase kinase 3? In Int J Cardiol. 183, pp. 39–46. Available online at PM:25662052; ISI:000351927700008.
    4. Kirchhof, P.; Tal, T.; Fabritz, L.; Klimas, J.; Nesher, N.; Schulte, J. S. et al. (2015): First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart. In Circ Heart Fail. 8 (1), pp. 79–88. Available online at PM:25424392; ISI:000348145400012.
    5. Kucerova, D.; Doka, G.; Kruzliak, P.; Turcekova, K.; Kmecova, J.; Brnoliakova, Z. et al. (2015): Unbalanced upregulation of ryanodine receptor 2 plays a particular role in early development of daunorubicin cardiomyopathy. In Am J Transl Res. 7 (7), pp. 1280–1294. Available online at PM:26328012; ISI:000361558000009.
    6. Matus, M.; Kucerova, D.; Kruzliak, P.; Adameova, A.; Doka, G.; Turcekova, K. et al. (2015): Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat. In Mol Cell Biochem. 403 (1-2), pp. 199–208. Available online at PM:25663023; ISI:000355432700020.
    7. Neumann, J.; Gergs, U.; Mueller, F. U.; Eskandar, J.; Drzewiecki, K.; Schmitz, W.; Boknik, P. (2015): OVEREXPRESSION OF HUMAN A2A RECEPTORS PROTECT THE HEART AGAINST ISCHEMIA. In Cardiology. 132 1, p. 130. Available online at ISI:000365668000117.
    8. Pluteanu, F.; Heß, J.; Plackic, J.; Nikonova, Y.; Preisenberger, J.; Bukowska, A. et al. (2015): Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats. In Cardiovasc Res. 106 (1), pp. 87–97. Available online at PM:25691541; ISI:000356182400014.
    9. Schotten, U.; Hatem, S.; Ravens, U.; Jaïs, P.; Müller, F. U.; Goette, A. et al. (2015): The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. In Europace. 17 (10), pp. 1457–1466. Available online at PM:26364316; ISI:000366488600001.
    10. Schulte, J. S.; Fehrmann, E.; Tekook, M. A.; Heinick, A.; Mueller, F. U. (2015): Studying arrhythmogenic events in mouse cardiomyocytes. In Acta Physiol (Oxf). 213 699, p. 35. Available online at ISI:000362554200072.
    11. Seidl, M. D.; Steingräber, A. K.; Wolf, C. T.; Sur, T. M.; Hildebrandt, I.; Witten, A. et al. (2015): Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice. In Pflugers Arch. 467 (10), pp. 2165–2177. Available online at PM:25425331; ISI:000361000800010.
    12. Walther, S.; Edwards, J. N.; Maxwell, J. T.; Pluteanu, F.; Renz, S.; Pieske, B.; Blatter, L. A. (2015): Urocortin 2 Regulates Sarcoplasmic Reticulum Calcium via Phosphorylation of Phospholamban and SERCA Activation and Protects against Pro-Arrhythmic Alternans in Cardiac Myocytes from Normal and Failing Hearts. In Biophys J. 108 1 (2), 264A-264A. Available online at ISI:000362849100543.
    13. Zhang, M.; Schulte, J. S.; Heinick, A.; Piccini, I.; Rao, J.; Quaranta, R. et al. (2015): Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation. In Stem Cells. 33 (5), pp. 1456–1469. Available online at PM:25639979; ISI:000353292600008.

  • 2014

    1. Kido-Nakahara, M.; Buddenkotte, J.; Kempkes, C.; Ikoma, A.; Cevikbas, F.; Akiyama, T. et al. (2014): Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus. In J Clin Invest. 124 (6), pp. 2683–2695. Available online at PM:24812665; ISI:000336868800039.
    2. Kirchhefer, U.; Brekle, C.; Eskandar, J.; Isensee, G.; Ku?erová, D.; Müller, F. U. et al. (2014): Cardiac function is regulated by B56?-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates. In J Biol Chem. 289 (49), pp. 33862–33873. Available online at PM:25320082; ISI:000346077600013.
    3. Kirchhefer, U.; Eskandar, J.; Mueller, F.; Boknik, P. (2014): HEART-DIRECTED OVEREXPRESSION OF THE PP2A REGULATORY SUBUNIT B56ALPHA PROTECTS AGAINST ISCHEMIC STRESS. In Basic Clin Pharmacol Toxicol. 115 1, p. 28. Available online at ISI:000356300900092.
    4. Kirchhefer, U.; Heinick, A.; König, S.; Kristensen, T.; Müller, F. U.; Seidl, M. D.; Boknik, P. (2014): Protein phosphatase 2A is regulated by protein kinase C? (PKC?)-dependent phosphorylation of its targeting subunit B56? at Ser41. In J Biol Chem. 289 (1), pp. 163–176. Available online at PM:24225947; ISI:000329370900015.
    5. Kirchhof, Paulus; Marijon, Eloi; Fabritz, Larissa; Li, Na; Wang, Wei; Wang, Tiannan et al. (2014): Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice (vol 166, pg 366, 2013). In Int J Cardiol. 172 (3), p. 631. Available online at ISI:000333101000086.
    6. Li, N.; Chiang, D. Y.; Wang, S.; Wang, Q.; Sun, L.; Voigt, N. et al. (2014): Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. In Circulation. 129 (12), pp. 1276–1285. Available online at PM:24398018; ISI:000335369800007.
    7. Paul, M.; Meyborg, M.; Boknik, P.; Gergs, U.; Gerss, J.; Schmitz, W. et al. (2014): Autonomic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy: biochemical evidence of altered signaling pathways. In Pacing Clin Electrophysiol. 37 (2), pp. 173–178. Available online at PM:24025189; ISI:000330683800006.
    8. Schulte, J. S.; Seidl, M. D.; Müller, F. U. (2014): The role of transcription factors in the formation of an arrhythmogenic substrate in congestive human heart failure. In Curr Med Chem. 21 (11), pp. 1281–1298. Available online at PM:23862616; ISI:000332942600003.
    9. Seidl, M. D.; Nunes, F.; Fels, B.; Hildebrandt, I.; Schmitz, W.; Schulze-Osthoff, K.; Müller, F. U. (2014): A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms. In FASEB J. 28 (1), pp. 143–152. Available online at PM:24022402; ISI:000333526100016.
    10. Walther, S.; Edwards, J. N.; Pluteanu, F.; Renz, S.; Schmidt, K.; Pieske, B. et al. (2014): Urocortin 2 Protects Against Pacing-Induced Alternans via Phosphorylation of Phospholamban in Cardiac Myocytes from Normal and Failing Hearts. In Biophys J. 106 1 (2), 116A-116A. Available online at ISI:000337000400586.
    11. Walther, S.; Pluteanu, F.; Renz, S.; Nikonova, Y.; Maxwell, J. T.; Yang, L. Z. et al. (2014): Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177. In Am J Physiol Heart Circ Physiol. 307 (5), H689-700. Available online at PM:25015964; ISI:000341081200007.

  • 2013

    1. Boegeholz, N.; Bauer, K. B.; Schulte, J. S.; Milberg, P.; Moennig, G.; Schmitz, W. et al. (2013): Dronedarone-mediated antiarrhythmic but not inotropic effects depend on Na+/Ca2+exchanger (NCX) activity: Investigations in NCX knockout and overexpressor mice. In Eur Heart J. 34 1, p. 926. Available online at ISI:000327744605453.
    2. Kempkes, Cordula; Buddenkotte, Joerg; Kido, Makiko; Cevikbas, Ferda; Buhl, Timo; Akiyama, Tasuku et al. (2013): ENDOTHELIN-1-INDUCED PRURITUS IS REGULATED BY ENDOTHELIN-CONVERTING ENZYME-1 IN MICE AND HUMANS. In Acta Derm Venereol. 93 (5), p. 625. Available online at ISI:000330327200108.
    3. Kirchhof, P.; Marijon, E.; Fabritz, L.; Li, N.; Wang, W.; Wang, T. et al. (2013): Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. In Int J Cardiol. 166 (2), pp. 366–374. Available online at PM:22093963; ISI:000319510200022.
    4. Sotoud, H.; Gribbon, P.; Ellinger, B.; Reinshagen, J.; Boknik, P.; Kattner, L. et al. (2013): Development of a colorimetric and a fluorescence phosphatase-inhibitor assay suitable for drug discovery approaches. In J Biomol Screen. 18 (8), pp. 899–909. Available online at PM:23606651; ISI:000323115300005.
    5. Stegemann, A.; Sindrilaru, A.; Eckes, B.; Del Rey, A.; Heinick, A.; Schulte, J. S. et al. (2013): Tropisetron suppresses collagen synthesis in skin fibroblasts via ?7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. In Arthritis Rheum. 65 (3), pp. 792–804. Available online at PM:23440693; ISI:000315452400030.

  • 2012

    1. Milberg P, Pott C, Frommeyer G, Fink M, Ruhe M, Matsuda T, Baba A, Klocke R, Quang TH, Nikol S, Stymann J, Osada N, Müller FU, Breithardt G, Noble D, Eckardt L (2012) Acute inhibition of the Na+/Ca2+ exchanger reduces proarrhythmia in an experimental model of chronic heart failure. Heart Rhythm: doi:10.1016/j.hrthm.2011.11.004
       
    2. Stallmeyer B, Zumhagen S, Denjoy I, Duthoit G, Hébert JL, Ferrer X, Maugenre S, Schmitz W, Kirchhefer U, Schulze-Bahr E, Guicheney P, Schulze-Bahr E (2012) Mutational spectrum in the Ca2+-activated cation channel gene TRPM4 in patients with cardiac conductance disturbances. Hum Mutat 33: 109-17.
       
    3. Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, Schmitz W, Philipson KD, Eckardt L, Kirchhof P, Müller FU (2012) Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca2+ exchanger overexpression: whole heart and cellular mechanisms. Basic Res Cardiol: doi:10.1007/s00395-012-0247-7
       
    4. Schulte JS, Seidl MD, Nunes F, Freese C, Schneider MD, Schmitz W, Muller FU (2012) CREB critically regulates action potential shape and duration in the adult mouse ventricle. Am J Physiol Heart Circ Physiol: doi:10.1152/ajpheart.00057.2011
       
    5. Kucerova D, Baba HA, Boknik P, Fabritz L, Heinick A, Matus M, Muller FU, Neumann J, Schmitz W, Kirchhefer U (2012) Modulation of SR Ca2+ release by the triadin-calsequestrin ratio in ventricular myocytes. Am J Physiol Heart Circ Physiol: doi:10.1152/ajpheart.00457.2011

    6. Gergs, Ulrich; Boknik, Peter; Buchwalow, IgorB; Fabritz, Larissa; Gruendker, Nicole; Kucerova, Dana et al. (2012): Modulation of cardiac contractility by serine/threonine protein phosphatase type 5. In Int J Cardiol. 154 (2), pp. 116–121. Available online at PM:20875921; ISI:000299317200015.

  • 2011

    1. Paul M, Meyborg M, Bokník P, Gergs U, Schmitz W, Breithardt G, Wichter T, Neumann J (2011) Autonomic dysfunction in patients with Brugada syndrome: further biochemical evidence of altered signaling pathways. Pacing Clin Electrophysiol 34: 1147-53.
       
    2. Wijnker PJM, Bokník P, Gergs U, Müller FU, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJM, van der Velden J, Kirchhefer U (2011) Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium. J Muscle Cell Motil 32: 221-33.
       
    3. Gergs U, Kirchhefer U, Buskase J, Kiele-Dunsche K, Buchwalow IB, Jones LR, Schmitz W, Traub O, Neumann J (2011) Sarcoplasmic reticulum Ca2+ release in neonatal rat cardiac myocytes. J Moll Cell Cardiol 51: 682-8.
       
    4. Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wesels S, Schotten U, Moubarak G, Wehrens XHT, Schmitz W, Hatem S, Müller FU (2011) Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol, doi:10.1016/j.ijcard.2011.10.057
       

  • 2010

    1. Müller-Tidow C, Klein HU, Hascher A, Isken F, Tickenbrock L, Thoennissen N, Agrawal-Singh S, Tschanter P, Wang Y, Becker A, Thiede C, Ehninger G, zur Stadt U, Koschmieder S, Seidl M, Müller FU, Schmitz W, Schlenke P, McClelland M, Berdel WE, Dugas M, Serve H: Profiling of Histone H3 lysine 9 trimethylation levels predicts Transcription Factor Activity and Survival in Acute Myeloid Leukemia. Blood, in press, 2010
       
    2. Kirchhefer U, Wehrmeister D, Postma AV, Pohlentz G, Mormann M, Kucerova D, Müller FU, Schmitz W, Schulze-Bahr E, Wilde AA., Neumann J: The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling, Journal of Molecular and Cellular Cardiology (2010), doi: 10.1016/j.yjmcc.2010.03.006
       
    3. Krieglstein J, Kewitz T, Kirchhefer U, Hofnagel O, Weißen-Plenz G, Reinbold M, Klumpp S (2010) Damage of Guinea Pig Heart and Arteries by a Triolate-Enriched Diet and of Cultured Cardiomyocytes by Oleic Acid. PLoS ONE 5(3): e9561. doi:10.1371/journal.pone.0009561
       
    4. Fabritz L, Damke D, Emmerich M, Kaufmann SG, Theis K, Blana A, Fortmüller L, Laakmann S, Hermann S, Aleynichenko E, Steinfurt J, Volkery D, Riemann B, Kichhefer U, Franz MR, Breithardt G, Carmeliet E, Schäfers M, Maier SKG, Carmeliet P, Kirchhof P (2010) Autonomic modulation and antiarrythmic therapy in a modul of long QT syndrome type 3. Cardiovasc Res 87: 60-72.
       
    5. Gergs U, Baumann M, Böckler A, Buchwalow IB, Ebelt H, Fabritz L, Haupt-mann S, Keller N, Hirchhof P, Klöckner U, Pönicke K, Rueckschloss U, Schmitz W, Werner F, Neumann J (2010) Cardiac overexpression of the human 5-HT4 receptor in mice. Am J Physiol Heart Circ Physiol 299: H788-98
       
    6. Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Bokník P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJM, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S (2010) Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ Arrythm Electrophysiol 3: 530-41.
       
    7. Gergs U, Bokník P, Buchwalow IB, Fabritz L, Gründker N, Kucerova D, Matus M, Werner F, Schmitz W, Neumann J (2010) Modulation of cardiac contractility by serine/threonine protein phosphatase type 5. Int J Cardiol (2010), doi:10.1016/j.ijcard.2010.09.009
       
    8. Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, Bragt KV, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithard G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P, Fabritz L (2010) Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm (2010), doi:10.1016/j.hrthm.2010.08.016
       
    9. Sunderkötter C, Kirchhefer U (2010) Geringe Toxizität der Läusemittel Pyrethrin, Pyrethroide und Permethrin. Hautarzt 2010, 61: 906-909.

  • 2009

    1. Lewin G, Matus M, Basu A, Frebel K, Rohsbach SP, Safronenko A, Seidl MD, Stümpel F, Buchwalow I, König S, Engelhardt SH, Lohse MJ, Schmitz W, Müller FU (2009) Critical role of transcription factor CREM in ß1-adrenoceptor-mediated cardiac dysfunction. Circulation 119: 79-88
       
    2. Ahlmann M, Varga G, Sturm K, Lippe R, Bedenyk K, Vielmann D, Scholzen T, Ehrchen J, Müller FU, Seidl M, Matus M, Tsokos GC, Roth J, Tenbrock K (2009) The Cyclic AMP Response Element Modulator a Suppresses CD86 Expression and APC Function. J Immunol 182(7): 4167-74
       
    3. Greiser M, Neuberger HR, Harks E, El-Armouche A, Bokník P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U (2009) Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilation and atrial fibrillation. J Mol Cell Cardiol 46(3): 385-94
       
    4. Gergs U, Bokník P, Schmitz W, Simm A, Silber RE, Neumann J (2009) A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts. Naunyn Schmiedebergs Arch Pharmacol 379(5): 533-40
       
    5. Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapuro DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XHT (2009) Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest 119: 1940-51
       
    6. Bokník P, Grote-Wessels S, Barteska G, Jiang M, Müller FU, Schmitz W, Neumann J, Birnbaumer L (2009) Genetic disruption of G proteins, Gi2a or Goa, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium. Brit J Pharmacol 158: 1557-64

  • 2008

    1.  Gergs U, Bokník P, Schmitz W, Simm A, Silber RE, Neumann J (2008) A positive inotropic effect of ATP in the human cardiac atrium. Am J Physiol Heart Circ Physiol 294: H1716-1723
       
    2. Grote-Wessels S, Baba HA, Bokník P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U (2008) Inhibition of protein phospatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. Cardiovascular Research 79: 464-471.
       
    3. Brüchert N, Mavila N, Bokník P, Baba HA, Fabritz L, Gergs U, Kirchhefer U, Kirchhof P, Matus M, Schmitz W, De Paoli-Roach AA, Neumann J (2008) Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality. Am J Physiol Heart Circ Physiol 295: H1539-1546.
       
    4. Schwoerer AP, Neuber C, Schmechel A, Melnychenko I, Mearini G, Bokník P, Kirchhefer U, Schmitz W, Ehmke H, Eschenhagen T, El-Armouche A (2008) Mechanical unloading of therat heart involves marked changes in the protein kinase-phosphatase balance. J Mol Cell Cardiology 45: 846-852
       
    5. Kelber O, Gaedcke F, Steinhoff B, Winterhoff H (2008) Ethanol in Herbal Medicinal Products for Children. Pharm Ind 70, 9: 1124-1127
       
    6. Lüss H, Mitrovic V, Seferovic PM, Simeunovic D, Ristic AD, Moiseyev VS, Forssmann W-G, Hamdy AM, Meyer M (2008) Renal effects of ularitide in patients with decompensated heart failure. Am Heart J 155(6): 1012.e1-8
       
    7. Yeh YH, Wakili R, Qi XY, Chartier D, Bokník P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S (2008) Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol 1: 93-102

  • 2007

    1. Punkt K, Schering S, Fritzsche M, Asmussen G, Minin EA, Samoilova VE, Müller FU, Schmitz W, Hasselblatt M, Paulus W, Müller-Werdan U, Slezak J, Koehler G, Boecker W, Buchwalow IB (2007) Fibre-related nitric oxide synthase (NOS) in Duchenne muscular dystrophy. Acta Histochem 109: 228-236.
       
    2. Matus M, Lewin G, Stümpel F, Buchwalow IB, Schneider MD, Schütz G, Schmitz W, Müller FU (2007) Cardiomyocite-specific inactivation of trans-cription factor CREB in mice. FASEB J 21: 1884-1892.
       
    3. Kirchhof P, Klimas J, Fabritz L, Zwiener M, Jones LR, Schäfers M, Hermann S, Bokník P, Schmitz W, Breithardt G, Kirchhefer U, Neumann J (2007) Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin. J Mol Cell Cardiol 42: 962-971.
       
    4. Gergs U, Berndt T, Buskase J, Jones LR, Kirchhefer U, Müller FU, Schlüter KD, Schmitz W (2007) On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol 293: H728-H734.
       
    5. Greiser M, Halaszovich CR, Frechen D, Bokník P, Ravens U, Dobrev D, Lückhoff A, Schotten U (2007) Pharmacological evidence for altered src kinase regulation of ICa,L in patients with chronic atrial fibrillation. Naunyn-Schmiedeberg’s Arch Pharmacol 375: 383-392.
       
    6. Kirchhefer U, Klimas J, Baba HA, Buchwalow IB, Fabritz L, Hüls M, Matus M, Müller FU, Schmitz W, Neumann J (2007) Triadin is a critical determinant of cellular Ca cycling and contractility in the heart. Am J Physiol Heart Circ Physiol 293: H3165-3174.

  • 2006

    1. Kirchhefer U, Hanske G, Jones LR, Justus I, Kaestner L, Lipp P, Schmitz W, Neumann J (2006) Overexpression of junctin causes adaptive changes in cardiac myocyte Ca2+ signaling. Cell Calcium 39: 131-142.
       
    2. Buchwalow IB, Minin EA, Müller FU, Lewin G, Samoilova VE, Schmitz W, Wellner M, Hasselblatt M, Punkt K, Müller-Werdan U, Demus U, Slezak J, Koehler G, Boecker W (2006) Nitric oxide synthase in muscular dystrophies: a re-evaluation. Acta Neuropathol 111: 579-588.
       
    3. Weber T, Neumann J, Meißner A, Große Hartlage M, Van Aken H, Hanske G, Schmitz W, Bokník P (2006) Reduced serine-16 and threonine-17 phospholamban phosphorylation in stunning of conscious dogs. Basic Res Cardiol 101: 253-260.
       
    4. Punkt K, Schering S, Löffler S, Minin EA, Samoilova VE, Hasselblat M, Paulus W, Müller-Werdan U, Demus U, Koehler G, Boecker W, Buchwalow IB (2006) Nitric oxide synthase is up-regulated in muscle fibers in muscular dystrophy. Biochem Biophys Res Commun 348: 259-64.
       
    5. Knapp J, Aleth S, Balzer F, Gergs U, Schmitz W, Neumann J (2006) Comparison of Contractile Responses in Isolated Mouse Aorta and Pulmonary Artery. Influence of Strain and Sex. J Cardiovasc Pharmacol 48: 820-826.
       
    6. Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H (2006) Sedating effects of Humulus lupulus L. extracts. Phytomedicine 13: 535-541.
       
    7. Fischer H, Fischer J, Bokník P, Gergs U, Schmitz W, Domschke W, Konturek JW, Neumann J (2006) Reduced expression of Ca2+ -regulating proteins in the upper gastrointestinal tract of patients with achalasia. World J Gastroenterol 12(37): 6002-6007.
       
    8. El-Armouche A, Bokník P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D (2006) Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation. Circulation 114: 670-680.

  • 2005

        1. Müller FU, Lewin G, Baba HA, Bokník P, Fabritz L, Kirchhefer U, Kirchhof P, Loser K, Matus M, Neumann J, Riemann B, Schmitz W (2005) Heart-directed Expression of a Human Cardiac Isoform of cAMP-Response Element Modulator in Transgenic Mice. J Biol Chem 280: 6906-6914.

        2. Buchwalow IB, Minin EA, Samoilova VE, Boecker W, Wellner M, Schmitz W, Neumann J, Punkt K (2005) Compartmentalization of NO signaling cascade in skeletal muscles. Biochem Bioph Res Co 330: 615-621.

       3. Müller FU (2005) Increased eNOS expression as a compensatory mechanism reducing b-adrenergic responsiveness? Cardiovasc Res 67: 575-577.

        4. Kirchhefer U, Baba HA, Bokník P, Breeden KM, Mavila N, Brüchert N, Justus I, Matus M, Schmitz W, DePaoli-Roach AA, Neumann J (2005) Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2. Cardiovasc Res 68: 98-108.

        5. Vahlhaus C, Neumann J, Lüss H, Wenzelburger F, Tjan TDT, Hammel D, Scheld HH, Schmitz W, Breithardt G, Wichter T (2005) Ischemic preconditioning by unstable angina reduces the release of CK-MB following CABG and stimulates left ventricular HSP-72 protein expression. J Card Surg 20: 412-419.

        6. Doetkotte R, Opitz K, Kiianmaa K, Winterhoff H (2005) Reduction of voluntary ethanol consumption in alcohol-preferring alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol 522: 72-77.

        7. Vonhoff C, Baumgartner A, Hegger M, Korte B, Biller A, Winterhoff H (2005) Extract of Lycopus europaeus L. reduces cardiac signs of hyperthyroidism in rats. Life Sci 78: 1063-70. 

     

  • 2004

    1. Buchwalow IB, Podzuweit T, Samoilova VE, Wellner M, Haller H, Grote S, Aleth S, Boecker W, Schmitz W, Neumann J (2004) An in situ evidence for autocrine function of NO in the vasculature. Nitric Oxide 10: 203-212.
       
    2. Hahnenkamp K, Durieux ME, van Aken H, Berning S, Heyse TJ, Hönemann CW, Linck B (2004) Modulation of Xenopus laevis Ca-activated CI currents by protein kinase C and protein phosphatases: implications for studies of anesthetic mechanisms. Anesth Analg 99: 416-422.
       
    3. Christ T, Boknik P, Wöhrl S, Wettwer E, Graf EM, Bosch RF, Knaut M, Schmitz W, Ravens U, Dobrev D (2004) L-Type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases. Circulation 110: 2651-2657.
       
    4. Kuhn M, Voß M, Mitko D, Stypmann J, Schmid C, Kawaguchi N, Grabellus F, Baba HA (2004) Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure. Cardiovasc Res 64: 308-314.
       
    5. Kirchhefer U, Baba HA, Hanske G, Jones LR, Kirchhof P, Schmitz W, Neumann J (2004) Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin. Am J Physiol Heart Circ Physiol 287: H2216-H2225.
       
    6. Potthast R, Abbey-Hosch SE, Antos LK, Marchant JS, Kuhn M, Potter LR (2004) Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-b/guanylyl cyclase-b. J Biol Chem 279: 48513-48519.
       
    7. Gergs U, Boknik P, Buchwalow I, Fabritz L, Matus M, Justus I, Hanske G, Schmitz W, Neumann J (2004) Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function. J Biol Chem 279: 40827-40834.
       
    8. Skryabin BV, Holtwick R, Fabritz L, Kruse MN, Veltrup I, Stypmann J, Kirchhof P, Sabrane K, Bubikat A, Voß M, Kuhn M (2004) Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by aMHC-cre-mediated recombination. Gene 39: 288-298.
       
    9. Slezak J, Buchwalow IB, Schulze W, Karczewski P, Wallukat G, Samoilova VE, Krause E-G, Neumann J, Haller H (2004) Cellular Control of Nitric Oxide Synthase Expression and Activity in Rat Cardiomyocytes. Antioxidants & Redox Signaling 6 (2): 345-352.
       
    10. Steinmetz M, Potthast R, Sabrane K, Kuhn M (2004) Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice. Regul Peptides 119: 31-37.
       
    11. Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ,
      Riemann B, Schmitz W, Stypmann J, Neumann J (2004) Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to ß-adrenergic agonists. Cardiovasc Res 62: 122-134.
       
    12. Fabritz L, Kirchhof P, Fortmüller L, Auchampach JA, Baba HA, Breithardt G, Neumann J, Boknik P, Schmitz W (2004) Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A3 adenosine receptors. Cardiovasc Res 62: 500-508.
       
    13. Kirchhof P, Fabritz L, Kilic A, Begrow F, Breithardt G, Kuhn M (2004) Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice. J Mol Cell Cardiol 36: 691-700.
       
    14. El-Armouche A, Jaeckel E, Boheler KR, Boknik P, Hertle B, Neumann J, Eschenhagen T (2004) Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca2+ -exchanger and ß-adrenergic sensitization in rat hearts. Biochem Bioph Res Co 318: 219-226.
       
    15. Luo J, Jankowski V, Güngär N, Neumann J, Schmitz W, Zidek W, Schlüter H, Jankowski J (2004) Endogenous Diadenosine Tetraphosphate, Diadenosine Pentaphosphate, and Diadenosine Hexaphosphate in Human Myocardial Tissue. Hypertension 43: 1055-1059.
       
    16. Van der Voort IR, Knapp J, Konturek JW, Bokník P, Domschke W, Schmitz W, Neumann J (2004) Expression and functional role of serine/ threonine phosphatases in rat esophagus. Med Sci Monit 10(5): BR123-129

  • 2003

    1.     Winterhoff H, Spengler B, Christoffel V, Butterweck V, Löhning A (2003)Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity. Maturitas 44 (suppl. 1) S51-S58.

    2.     Kopka K, Wagner S, Riemann B, Law MP, Puke C, Luthra SK, Pike VW, Wichter T, Schmitz W, Schober O, Schäfers M (2003) Design of new ß1-selective adrenoceptor ligands as potential radioligands for in vivo imaging. Bioorgan Med Chem 11: 3513-3527.

    3.     El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann W-H, Jäckel E, Harding SE, Boknik P Neumann J, Eschenhagen T (2003) Evidence for protein phosphatase inhibitor-1 playing an amplifier role in ß-adrenergic signaling in cardiac myocytes. FASEB 17: 437-439.

    4.     Butterweck V, Simbrey K, Seo S, Sasaki T, Nishibe S (2003) Long-term effects of an Apocynum venetum extract on brain monoamine levels and ß-AR density in rats. Pharmacol Biochem Be 75: 557-564.

    5.     Butterweck V, Winterhoff H, Herkenham M (2003) Hyperforin-containing extracts of St John’s wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats. Neuropsychopharmacol 28: 2160-2168.

    6.     Butterweck V (2003) Mechanism of action of St John’s wort in depression . What is known? CNS Drugs 17(8): 539-562. 

  • 2002

    1.      Kuhn M, Holtwick R, Baba H A, Perriard J C, Schmitz W, Ehler E ( 2002) Progressive cardiac hypertrophy and dysfunction in atrial natriuretic peptide receptor ( GC-A) deficient mice.
    Heart 87: 368-374

    2.      Butterweck V, Böckers T, Korte B, Wittkowski W, Winterhoff H (2002) Long-term effects of St. John´s wort and hypericin on monoamine levels in rat hypothalamus and hippocampus.
    Brai Res 930: 21-29

    3.      Ramesh C G, Neumann J, Watanabe A M, Sabbah H N (2002) Inhibition of type 1 protein phosphatase activity by activation of ß-adrenoceptors in ventricular myocardium.
    Biochem Pharmacol 63: 1069-1076

    4.      Pierkes M, Gambaryan S, Boknik P, Lohmann S M, Schmitz W, Potthast R, Holtwick R, Kuhn M (2002) Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice.
    Cardiovasc Res 53: 852-861

    5.      Holtwick R, Gotthardt M, Skryabin B, Steinmetz M, Potthast R, Zetsche B, Hammer R E, Herz J, Kuhn M (2002) Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
    PNAS 99: 7142-7147

    6.      Lüß H, Schmitz W, Neumann J (2002) A proteasome inhibitor confers cardioprotection. Cardiovasc Res 54: 140 –150

    7.      Kirchhefer U, Baba A H, Kobayashi Y M, Jones R J, Schmitz W, Neumann J (2002) Altered function in atrium of transgenic mice overexpressing triadin 1. Am J Physiol Heart Cir Physiol 280: H1334-H1343, 2002

    8.      Lüss H, Schäfers M, Neumann J, Hammel D, Vahlhaus C, Hideo A B, Janssen F, Scheld H H, Schober O, Breithardt G, Schmitz W, Wichter T (2002) Biochemical mechanisms of hibernation and stunning in the human heart. Cardiovasc Res 56: 411-421

    9.      Knapp J, Aleth S, Balzer F, Schmitz W, Neumann J (2002) Calcium-independent activationof the contractile apparatus in smooth muscle of mouse aorta by protein phosphatase inhibition. Naunyn-Schmiedeberg`s Arch Pharmacol 366: 562-569

    10.    Müller F U, Lewin G, Matus M, Neumann J, Riemann B, Wistuba J, Schütz G, Schmitz W (2002) Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene. FASEB J express article 10.1096/fj.02-0486fje. Published online November 15, 2002

  • 2001

    1.      Schulz R, Post H, Neumann T, Gres P, Lüss H and Heusch G (2001) Progressive loss of perfusion-contraction matching during sustained moderate ischemia in pigs
    Am J Physiol Heart Circ Physiol 280: H1945-H1953, 2001

    2.      Konturek JW, Fischer H, Konturek PC, Huber V, Boknik P, Lüss H, Neumann J, Brzozowski T, Schmitz W, Hahn EG, Domschke W, Konturek SJ (2001) Heat shock protein 70 (HSP70) in gastric adaptation to aspirin in heliobacter pylori infection
    J Physiol Pharmacol 2001 Mar;52(1): 153-64

    3.      Fischer H, Huber V, Boknik P, Lüss H, Neumann J, Schmitz W, Domschke W,  Konturek JW (2001) Effekt of Helicobacter pylori eradication on cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression during gastric adaptation to aspirin (ASA) in humans
    Microscopy research and Technique 53: 336-342 (2001)

    4.      Boknik P, Heinroth-Hoffmann I, Kirchhefer U, Knapp J, Linck B, Lüss H, Müller Th, Schmitz W, Brodde OE, Neumann J (2001) Enhanced protein phosphorylation in hypertensive hypertrophy
    Cardiovasc Res 1: in press (2001)

    5.      Müller FU, Boknik P, Knapp J, Linck B, Lüss H, Neumann J, Schmitz W, (2001) Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes
    Cardiovasc Res 1: in press (2001)

    6.      Potthast R, Ehler E, Scheving LA, Sindic A, Schlatter E, Kuhn M (2001) High salt intake increases uroguanylin expression in mouse kidney
    Endocrinology 142 (7): 3087-3097 (2001)

    7.      Butterweck V, Sansei N, Tsutomu S, Masaru U (2001) Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.
    Biol. Pharm. Bull. 24 (7): 848-851 (2001)

    8.      Butterweck V, Korte B, Winterhoff H (2001) Pharmacological and Endocrine Effects of Hypericum Perforatum and Hypericin After Repeated Treatment.
    Pharmacopsychiatry 34 (Suppl. 1): 52-57 (2001)

    9.      Weber ThP, Meissner A, Boknik P, Grosse Hartlage M, Möllhoff Th, van Aken H, Rolf N (2001) Hemin, Inducer of Heme-Oxygenase 1, Improves Functional Recovery From Myocardial Stunning in Conscious Dogs.
    Journal of Cardiothoracic and Vascular Anesthesia 15 (4): 422-427

    10.    Butterweck V, Winterhoff H, Herkenham M (2001) St John´s wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats.
    Molecular Psychiatry 6: 547-564

    11.    Linck B, Boknik P, Knapp J, Kikuchi K, Lüß H, Müller F U, Nomoto K, Neumann J, Schmitz W (2001) Functional properties of the rat phosphatase 1a promoter.
    Molecular and Cellular Biochemistry 223: 123-129

    12.    Hönemann C, Heyse T J, Möllhoff T, Hahnenkamp K, Berning S, Hinder F, Linck B, Schmitz W, Van Aken H (2001) The Inhibitory Effect of Bupivacaine on Prostglandin E2 (EP1) Receptor Functioning: Mechanism of Action.
    Anest Analg 93: 628-634

    13.    Mehrhof F B, Müller F U, Bergmann M W, Li P, Wang Y, Schmitz W, Dietz R, Von Harsdorf R (2001) In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol –3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
    Circulation 104: 2088-2094

    14.    Engelhardt S, Boknik P, Keller U, Neumann J, Lohse M J, Hein L (2001) Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the ß1-adrenergic receptor.
    FASEB J 15: 2718-2720 

  • 2000

    1.      Kreuzberg U, Theissen P, Schischa H, Schröder F, Mehlhorn, De Vivie ER, Boknik P, Neumann J, Grohe C, Herzig S (2000) Single-channel activity and expression of atrial L-type Ca2+ channels in patients with latent hyperthyroidism.
    Am J Physiol 278: 723-730

    2.      Kruse SO, Löhning A, Pauli GF, Winterhoff H, Nahrstedt A (1999) Fukiic and piscidic acid ester from the rhizome of cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid.
    Planta Med 65: 763-764

    3.      Butterweck V, Jürgenliemk G, Nahrstedt A, Winterhoff H (2000) Flavonoids from hypericum perforatum show antidepressant activity in the forced swimming test.
    Planta Med 65: 3-6

    4.      Meissner A, Lüss I, Rolf N, Bokník P, Kirchhefer U, Vadim K, Knapp J, Linck B, Lüss H, Müller FU, Weber T, Schmitz W, Van Aken H, Neumann J (2000) The early response genes c-jun and HSP-70 are induced in regional cardiac stunning in conscious mammals.
    J Thorac Cardiov Sur 119: 820-825

    5.      Linck B, Schmitz W (2000) Messenger RNA expression and immunological quantification of phospholamban and SR-Ca2+-ATPase in failing and nonfailing human hearts.
    Cardiovasc Res 45: 243-244

    6.      Gupta RC, Neumann J, Watanabe AM, Sabbah HN (2000) cAMP-independent muscarinic-cholinergic inhibition of forskolin-induced protein phosphorylation in ventricular cardiomyocytes.
    Exp Physiol 4(1): 23-28

    7.      Herzig S, Neumann J (2000) Effects of serine/threonine protein phosphatases on ion channels in excitable membranes.
    Physiol Rev 80: 173-210

    8.      Lüss H, Meissner A, Rolf N, Van Aken H, Bokník P, Kirchhefer U, Knapp J, Läer S, Linck B, Lüss I, Müller FU, Neumann J, Schmitz W (2000) Biochemical mechanism(s) of stunning in conscious dogs.
    Am J Physiol 279: 176-184

    9.      Bokník P, Vahlensieck U, Huke S, Knapp J Linck B, Lüss H, Müller FU, Neumann J, Schmitz W (2000) On the cardiac contractile, electrophysiological and biochemical effects of endothall, a protein phosphatase inhibitor.
    Pharmacology 61: 43-50

    10.   Knapp J, Boknik P, Linck B, Lüss H, Müller FU, Petertönjes L, Schmitz W, Neumann J (2000) Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion.
    J Pharmacol Exp Ther 294(2): 620-626

    11.   Mehrens T, Lelleck S, Cetinkaya I, Knollmann M, Hohage H, Gorboulev V, Boknik P, Koepsell H, Schlatter E (2000) The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation.
    J Am Soc Nephrol 11: 1216-1224

    12.   Linck B, Boknik P, Huke S, Kirchhefer U, Knapp J, Lüss H, Müller FU, Neumann J, Tanriseven S, Vahlensieck U, Baba HA, Jones LR, Philipson KD, Schmitz W (2000) Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na+-Ca2+ exchanger.
    J Pharmacol Exp Ther 294(2): 648-657

    13.   Zimmermann N, Nacke PR, Neumann J, Winter J, Gams E (2000) Inotropic effects of diadenosine monophosphate (AP1A) in isolated human cardiac preparations.
    J Cardiovasc Pharmacol 35(6): 881-886

    14.   Bokník P, Fockenbrock M, Herzig S, Knapp J, Linck B, Lüss H, Müller FU, Müller T, Schmitz W, Neumann J (2000) Protein phosphatase activity is increased in a rat model of long-term ß-adrenergic stimulation.
    Naunyn-Schmiedeberg`s Arch Pharmacol 362(3): 222-231

    15.   Bokník P, Khorchidi S,Bodor GS, Huke S, Knapp J, Linck B, Lüss H, Müller FU, Schmitz W, Neumann J (2001) Role of protein phosphatases in the regulation of cardiac inotropy and relaxation.
    Am J Physiol 280: H786-H794

    16.   Lüss H, Neumann J, Schmitz W, Schulz R, Heusch G (2000) The stress-responsive MAP kinase p38 is activated by low-flow ischemia in the in situ porcine heart.
    J Mol Cell Cardiol 32: 1787-1794

    17.   Lüss H, Klein-Wiele O, Boknik P, Herzig S, Knapp J, Linck B, Müller F U, Scheld H H, Schmid C, Schmitz W, Neumann J (2000) Regional expression of protein phosphatase type 1 and 2a catalytic subunit isoforms in the human heart.
    J Mol Cell Cardiol 32: 2349-2359

    18.   Kirchhefer U, Neumann J, Baba H A, Begrow F, Kobayashi Y M, Reinke U, Schmitz W, Jones L R (2001) Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing  triadin 1.
    J Biol Chem 276: 4142-4149

    19.   Müller FU, Neumann J and Schmitz W (2000) Transcriptional regulation by cAMP in the heart
    Mol Cell Biochem 212: 11-17,2000

  • 1999

    1.      Neumann J, Meissner A, Bokník P, Gombosová I, Knapp J, Lüß H, Müller FU, Schlüter H, Zidek W, Rolf N, van Aken H, Vahlensieck U, Schmitz W (1999) Inotropic effects of diadenosine tetraphosphate in the canine heart.
    J Cardiovasc Pharmacol 33:151-156

    2.      Vahlensieck U, Bokník P, Gombosová I, Huke S, Knapp J, Linck B, Lüß H, Müller FU, Neumann J, Deng MC, Scheld HH, Jankowski H, Schlüter H, Zidek W, Zimmermann N, Schmitz W (1999) Inotropic effects of diadenosine tetraphosphate (AP4A) in human and animal cardiac preparations. Differences in comparison to other mammalian hearts.
    J Pharmacol Exp Ther 288:805-813

    3.      Kirchhefer U, Schmitz W, Scholz H, Neumann J (1999) Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
    Cardiovasc Res 42: 254-261

    4.      Neumann J, Bartel S, Eschenhagen T, Haverich A, Hirt S, Karczewski P, Krause EG, Schmitz W, Scholz H, Stein B, Thoenes M (1999) Dissociation of the effects of forskolin and dibutyryl cAMP on force of contraction and phospholamban phosphorylation in human heart failure.
    J Cardiovasc Pharmacol 32: 157-162

    5.      Luo J, Jankowski J, Knobloch M, Van der Griet M, Gardanis K, Russ T, Vahlensieck U, Neumann J, Schmitz W, Tepel M, Deng MC, Zidek W, Schlüter H (1999) Idendification and charakterization of diadenosine 5', 5'''- P1, P2-diphosphate and diadenosine 5', 5'''-P1, P3-triphosphate in human myocardial tissue.
    FASEB J 13: 695-705

    6.      Flesch M, Kilter H, Cremers B, Laufs U, Südkamp M, Ortmann M, Müller FU, Böhm M (1999) Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite. J Am Cell Cardiol 33: 1062-1070

    7.      Neumann J, Maas R, Boknik P, Jones LR, Zimmermann N, Scholz H (1999) Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts.J Pharmacol Exp Ther 289: 188-193

    8.      Fischer H, Becker JC, Bokník P, Huber V, Lüß H, Neumann J, Schmitz W, Domschke W, Konturek JW (1999) Expression of endothelial cell-derived nitric oxide synthase (eNOS) is increased during gastric adaptation to chronic aspirin intake in humans.
    Aliment Pharmacol Ther 13: 507-514

    9.      Fischer H, Becker JC, Bokník P, Huber V, Lüß H, Neumann J, Schmitz W, Domschke W, Konturek JW (1999) Expression of constitutive nitric oxide synthase in rat and human gastrointestinal tract.
    Biochim Biophys Acta 1450: 414-422

    10.    Bokník P, Unkel C, Kirchhefer U, Kleideiter U, Klein-Wiele O, Knapp J, Linck B, Lüß H, Müller FU, Schmitz W (1999) Vahlensieck U, Zimmermann N, Jones LR, Neumann J: Regional expression of phospholamban in the human heart.
    Cardiovasc Res 42: 67-76

    11.    Lüss I, Bokník P, Jones LR, Kirchhefer U, Knapp J, Linck B, Lüß H, Meissner A, Müller FU, Schmitz W, Vahlensieck U, Neumann J (1999) Expression of cardiac calcium regulatory proteins in atrium versus ventricle in different species. 
    J Mol Cell Cardiol 31: 1299-1314

    12.    Knapp J, Boknik P, Lüß I, Huke S, Linck B, Lüß H, Müller FU, Müller T, Nacke P, Noll T, Piper HM, Schmitz W, Vahlensieck U, Neumann J (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability.
    J Pharmacol Exp Ther 289: 1480-1486

    13.    Knapp J, Boknik P, Gumbinger HG, Linck B, Lüß H, Müller FU, Schmitz W, Vahlensieck U, Neumann J (1999) Quantitation of clobazam in human plasma using high-performance liquid chromatography
    J Chromatogr Sci 37: 145-149

    14.    Waurick R, Knapp J, Van Aken H, Bokník P, Neumann J, Schmitz W (1999) Effect of 2,3-butanedione monoxime on force of contraction and protein phosphorylation in bovine smooth muscle.
    Naunyn-Schmiedeberg`s Arch Pharmacol 359:484-492

    15.    Knapp J, Bokník P, Deng MC, Huke S, Lüss I, Klein-Wiele O, Linck B, Lüss H, Müller FU, Nacke P, Scheld HH, Schmitz W, Vahlensieck U, Neumann J (1999) On the contractile function of protein phosphatases in isolated human coronary arteries.
    Naunyn-Schmiedeberg`s Arch Pharmacol 360:464-472

    16.    Knapp J, Bokník P, Linck B, Läer S, Müller FU, Neumann J, Vahlensieck U, Schlüter H, Zidek W, Schmitz W (1999) Inositol-1,4,5-triphosphate increase by diadenosine tetraphosphate in preparations from failing human myocardium.
    Naunyn-Schmiedeberg`s Arch Pharmacol 360:354-357

    17.    Neumann J, Vahlensieck U, Boknik P, Linck B, Lüss H, Müller FU, Matherne GP, Schmitz W (1999) Functional studies in atrium overexpressing A1-adenosine receptors.
    Brit J Pharmacol 128: 1623-1629

    18.    Schotten U, Koenigs B, Rueppel M, Schoendube F, Boknik P, Schmitz W, Hanrath P (1999) Reduced myocardial sarcoplasmic reticulum Ca2+-ATPase protein expression in compensated and secondary human cardiac hypertrophy.
    J Mol Cell Cardiol 31: 1483-1494

    19.    Fischer H, Becker JC, Boknik P, Huber V, Lüss H, Neumann J, Schmitz W, Domschke W, Konturek JW (1999) Expression of nitric oxide synthase in rat and human gastrointestinal tract.
    Biochem Biophys Acta 14479: 1-9

  • 1998

    1.      Knapp J, Bokník P, Huke S, Lüß H, Müller FU, Müller T, Nacke P, Schmitz W, Vahlensieck U, Neumann J (1998) The mechanism of action of cantharidin in smooth muscle Br J Pharmacol 123: 911-919

    2.      Lüß H, Bokník P, Heusch G, Müller FU, Neumann J, Schmitz W, Schulz R (1998) Expression of calcium regulatory proteins in short term hibernation and stunning in the in situ porcine heart.Cardiovasc Res 37: 606-617

    3.      Gombosová I, Bokník P; Kirchhefer U, Knapp J, Lüß H, Müller FU, Müller T, Vahlensieck U, Schmitz W, Bodor GS, Neumann J (1998) Postnatal changes in contractile time parameters, cardiac calcium regulatory proteins and phosphatases.Am J Physiol 274: H2123-H2132

    4.      Linck B, Bokník P, Baba HA, Eschenhagen T, Haverkamp U, Jäckel E, Kirchhefer U, Knapp J, Läer S, Müller FU, Jones LR, Schmitz W, Scholz H, Syska A, Vahlensieck U, Neumann J (1998) Long term beta-adrenoceptor-mediated alteration in contractility and expression of phospholamban and SR-Ca++-ATPase in mammalian ventricle. J Pharmacol Exp Ther 286: 531-538

    5.      Zimmermann N, Bokník P, Gams E, Herzig JW, Neumann J, Scholz H (1998) Calcium sensitization as new principle of inotropic therapy in end-stage heart failure? Eur J Cardiothorac Surg14: 70-75

    6.      Neumann J, Scholz H (1998) Deferoxamine blocks interactions of fluoride and carbachol in isolated mammalian cardiac preparations.Eur J Pharmacol 350: 189-194

    7.      Läer S, Remmers F, Scholz H, Stein B, Müller FU, Neumann J (1998) Receptor mechanisms involved in the 5-HT-induced inotropic action in the rat isolated atrium.Br J Pharmacol 123: 1182-1188

    8.      Linck B, Qiu Z, He Z, Tong Q, Hilgemann DW, Philipson KD (1998) Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3).Am J Physiol 274: C415-C423

    9.      John M, Wiedenmann B, Kruhøffer M, Adermann K, Ankorina-Stark I, Schlatter E, Ahnert-Hilger G, Forssmann WG, Kuhn M (1998) Guanylin stimulates regulated secretion from human neuroendocrine pancreatic cells.Gastroenterology 114: 791-797

    10.    Butterweck V, Petereit F, Winterhoff H, Nahrstedt A (1998) Solubilized hypericin and pseudohypericin from hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med 64: 291-294

    11.    Knapp J, Bokník P, Huke S, Gombosová I, Linck B, Lüß H, Müller FU, Müller TNacke P, Schmitz W, Vahlensieck U, Neumann J (1998) Contractility and inhibition            of protein phosphatases by cantharidin. Gen Pharmacol 31: 729-733

    12.    Neumann J, Bokník P, DePaoli-Roach AA, Field LJ, Rockmann HA, Kobayashi YM, Kelley JS, Jones LR (1998) Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. J Mol Cell Cardiol 30: 1991-2002

    13.    Müller FU, Bokník P, Knapp J, Neumann J, Vahlensieck U, Oetjen E, Scheld HH, Schmitz W (1998) Identification and expression of a novel isoform of cAMP response element modulator in the human heart. FASEB J 12: 1191-1199

    14.    Hajjar RJ, Müller FU, Schmitz W, Schnabel P, Böhm M (1998) Molecular aspects of adrenergic signal transduction in cardiac failure. J Mol Med 76: 747-755

    15.    Gupta RC, Neumann J, Watanabe AM, Sabbah HN (1998) Muscarinic-cholinoceptor mediated attenuation of phospholamban phosphorylation induced by inhibition of phosphodiesterase in ventricular cardiomyocytes: Evidence against a cAMP-dependent effect Mol Cell Biochem 187: 155-161

    16.    Stein B, Kiehn J, Neumann J (1998) Regulation of adenosine receptor subtypes and cardiac dysfunction in human heart failure.

    16.    In Cardiovascular Biology of Purines (eds. Burnstock G, Dobson JG jr, Liang BT, Linden J) pp 108-125, Kluwer Academic Publishers, Dordrecht

    17.    Stange K, Pohlmeier H, Lübbesmeyer A, Gumbinger G, Schmitz W, Baumgart P (1998) Vaskulärer Ergotismus durch Getreidestaubinhalation.  Dtsch Med Wschr 123: 1547-1550

  • 1997

    1.      Knapp J, Boknik P, Linck B, Lüß H, Müller FU, Nacke P, Neumann J, Vahlensieck U, Schmitz W (1997) The effect of the protein phosphatases inhibitor cantharidin on ß-adrenoceptor-mediated vasorelaxation. Br J Pharmacol 120:421-428

    2.      Bokník P, Neumann J, Kaspareit G, Schmitz W, Scholz H, Vahlensieck U, Zimmermann N (1997) Mechanisms of the contractile effects of levosimendan in the mammalian heart.  J Pharmacol Exp Ther 280: 277-283

    3.      Bockmann J, Böckers TM, Winter C, Wittkowski W, Winterhoff H, Deufel Th, Kreutz MR (1997) Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3`- triiodothyronine, thyrotropin-releasing hormone, and pit-1 independent. Endocrinology 138: 1019-1028

    4.      Neumann J, Eschenhagen T, Jones LR, Linck B, Schmitz W, Scholz H, Zimmermann N (1997) Increased expression of cardiac phosphatases in patients with end-stage heart failure. J Mol Cell Cardiol 29: 265-272

    5.      Läer S, Scholz H, Uebeler Ph, Neumann J, Zimmermann N (1997) Quantification of diltiazem in human cardiac tissue using high-performance liquid chromatography. J Chromatogr Sci 35: 93-96

    6.      Läer S, Neumann J, Scholz H (1997) Interaction between sotalol and an antacid preparation. Br J Clin Pharmacol 43: 269-272

    7.      Von Heyden B, Jordan U, Schmitz W, Hertle L (1997) Urethral relaxation after electrostimulation in the  guinea pig is independent of nitric oxide. J Urology 157: 1509-1513

    8.      Lüß H, Li RK, Shapiro RA, Tzeng E, McGowan FX, Yoneyama T, Hatakeyama K, Geller DA, Mickle DAG, Simmons RL, Billiar TR (1997) Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL- 1, TNF, IFNg, and LPS. J Mol Cell Cardiol 29: 1153-1165

    9.      Li RK, Li G, Mickle DAG, Weisel RD, Merante F, Lüß H, Rao V, Christakis GT, Williams WG (1997) Overexpression of transforming growth factor-ß1 and insulin-like growth factor-I in patients with idiopathic hypertrophic cardiomyopathy. Circulation 96: 874-881

    10.    Müller FU, Bokník P, Knapp J, Lüß H, Neumann J, Vahlensieck U, Böhm M, Deng MC, Scheld HH, Schmitz W (1997) Quantification of the cAMP response element binding protein in ventricular nuclear protein from failing and nonfailing human hearts. Biochem Biophys Res Commun 236: 351-354

    11.    Neumann J, Scholz H, Zimmermann N (1997) Pharmacological profile of CGP 48506, a new positive inotropic agent. Cardiovasc Drug Rev 15: 174-186

    12.    Cornelius T, Holmer SR, Müller FU, Riegger GAJ, Schunkert H (1997) Regulation of the rat atrial natriuretic peptide gene after acute imposition of left ventricular pressure overload. Hypertension 30: 1348-1355

    13.    Butterweck V, Wall A, Liefländer-Wulf U, Winterhoff H, Nahrstedt A (1997) Effects of the total extract and fractions of hypericum perforatum in animal assays for antidepressant activity.Pharmacopsychiatry 30: 117-124

    14.    Bokník P, Neumann J, Schmitz W, Scholz H, Wenzlaff H (1997) Characterization of biochemical effects of CGS 21680C, an A2-adenosine receptor agonist, in the mammalian ventricle. J Cardiovasc Pharmacol 30: 750-758

    15.    Hirsch JR, Cermak R, Forssmann WG, Kleta R, Kruhoffer M, Kuhn M, Schafer JA, Sun D, Schlatter E (1997) Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway. Kidney Int 51: 473-476

    16.    Lilienthal H, Weinand-Härer A, Winterhoff H, Winneke G (1997) Effects of maternal exposure to 3,3´,4,4´-tetrachlorobiphenyl or propylthiouracil in rats trained to discriminate apomorphine from saline. Toxicol Appl Pharmacol 146: 162-169

    17.    Kuhn M, Fuchs M, Beck FX, Martin S, Jähne J, Klempnauer J, Abrahamse SL, Reckhemmer G, Forssmann WG (1997) Endothelin-1 potently stimulates chloride secretion and inhibits Na(+)-glucose absortion in human intestine in vitro. J Physiol (London) 499: 391-402

    18.    Lopez JM, Garbers DL, Kuhn M (1997) The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling. J Biol Chem 272: 23064-23068

    19.    Schulz S, Lopez JM, Kuhn M, Garbers DL (1997) Disruption of the guanylyl cylase C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin - resistant mice. J Clin Invest 100: 1590 - 1595

    20.    Klodt J, Kuhn M, Marx UC, Martin S, Roesch P, Forssmann WG, Adermann K (1997) Synthesis, biological activity and isomerism of guanylate cyclase C-activating peptides guanylin and uroguanylin. J Pept Res 50: 222-230

    21.    Mügge A, Oldenburg J, Schmitz W, Scholz H (1997) Functional evidence against the existence of ß2-adrenoceptors mediating positive inotropic effects in guinea-pig right ventricular myocardium. Naunyn-Schmiedeberg`s Arch Pharmacol 355: 74-78 

  • 1996

    1.      Ihl-Vahl R, Eschenhagen T, Kübler W, Marquetant R, Nose M, Schmitz W, Scholz H, Strasser RH (1996) Differential regulation of mRNA specific for ß1- and ß 2-adrenergic receptors in human failing hearts. Evaluation of the absolute cardiac mRNA levels by two independent methods. J Mol Cell Cardiol 28: 1-10

    2.      Eschenhagen T, Mende U, Diederich M, Hertle B, Memmesheimer C, Pohl A, Schmitz W, Scholz H, Steinfath M, Böhm M, Michel MC, Brodde OE, Raap A (1996) Chronic treatment with carbachol sensitizes the myocardium to cAMP-Induced arrhythmia. Circulation 93: 763-771

    3.      Gupta RC, Neumann J, Watanabe AM, Lesch M, Sabbah HN (1996) Evidence for presence and hormonal regulation of protein phosphatase inhibitor-1 in ventricular cardiomyocyte. Am J Physiol 270: H1159-H1164

    4.      Scholz H, Eschenhagen T, Neumann J, Stein B (1996) Receptor-mediated regulation of cardiac contractility: inotropic effects of alpha-adrenoceptor stimulation with phenylephrine and noradrenaline in failing human hearts. Molecular and Cellular Mechanisms of Cardiovascular Regulation. Springer Tokyo: 317-325

    5.      Linck B, Boknik P, Eschenhagen Th, Müller FU, Neumann J, Nose M, Jones LR, Schmitz W, Scholz H (1996) Messenger RNA expression and immunological quantification of phospholamban and SR-Ca2+-ATPase in failing and nonfailing human hearts. Cardiovasc Res 31: 625-632

    6.      Schmitz W, Boknik P, Linck B,  Müller FU (1996) Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure. Mol Cell Biochem 157: 251-258

    7.      Zimmermann N, Boknik P, Gams E, Herzig JW, Neumann J, Schmitz W, Scholz H, Wenzlaff H (1996) Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium. J Pharmacol Exp Ther 277: 1572-1578

    8.      Neumann J, Eschenhagen T, Grupp IL, Haverich A, Herzig JW, Hirt St, Kalmar P, Schmitz W, Scholz H, Stein B, Wenzlaff H, Zimmermann N (1996) Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium. J Pharmacol Exp Ther 277: 1579-1585

    9.      Läer St, Neumann J, Scholz H, Uebeler Ph, Zimmermann N (1996) Determination of sotalol in human cardiac tissue by high-performance liquid chromatography. J Chromatogr B 681: 291-298

    10.    Stein B, Bartel S, Kirchhefer U, Kokott S, Krause EG, Neumann J, Schmitz W, Scholz H (1996) Relation between contractile function and regulatory cardiac proteins in hypertrophied hearts. Am J Physiol 270: H2021-H2028

    11.    Lüß H, Nussler NC, Berger HG, Nussler AK (1996) Expression and detection of inducible nitric oxide synthase in experimental models of inflammation.  Methods 10: 51-60

    12.    Stein B, Frank P, Schmitz W, Scholz H, Thoenes M (1996) Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase. J Mol Cell Cardiol 28: 1631-1639

    13.    Vahlensieck U, Boknik P, Knapp J, Linck B, Müller FU, Neumann J, Herzig S, Schlüter H, Zidek W, Deng MC, Scheld HH, Schmitz W (1996) Negative chronotropic and inotropic effects exerted by diadenosine hexphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol 119: 835 - 844

    14.    Sigmund M, Jakob H, Becker H, Hanrath P, Schumacher C, Eschenhagen T, Schmitz W, Scholz H (1996) Effects of metoprolol on myocardial ß-adrenoceptors and Gia-proteins in patients with congestive heart failure. Eur J Clin Pharmacol 51: 127-132

    15.    Deng MC, Erren M, Lütgen A, Zimmermann P, Brisse B, Schmitz W, Assmann G, Breithardt G, Scheld HH (1996) Interleukin-6 correlates with hemodynamic impairment during dobutamine administration in chronic heart failure. Int J Cardiol 57: 129-134

    16.    Linck B, Boknik P, Knapp J, Müller FU, Neumann J, Schmitz W, Vahlensieck U (1996) Effects of cantharidin on force of contraction and phosphatase activity in nonfailing and failing human hearts.Br J Pharmacol 119: 545-550

    17.    Bartel S, Stein B, Eschenhagen T, Mende U, Neumann J, Schmitz W, Krause EG, Karczewski P, Scholz H (1996) Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts. Mol Cell Biochem 157: 171-179

    18.    Gumbinger HG, Winterhoff H, Nahrstedt A (1996) Stoffwechselprodukte von Lycopus europaeus-Inhaltsstoffen. HPLC und DAD-Detektion der Metabolite aus perfundierter Leber. In: Merck KGaA (ed) Chromatographie - Chronologie einer Analysentechnik. GIT Verlag GmbH, Darmstadt, pp 357-363.

    19.    Zimmermann N, Boknik P, Gams E, Gsell S, Jones LR, Maas R, Neumann J, Scholz H (1996) Mechanism of the contractile effects of 2,3- butanedione-monoxime in the Mammilian heart. Naunyn Schmiedebergs Arch Pharmacol 354: 431-436

    20.    Seebeck J, Schmidt WE, Kilbinger H, Neumann J, Zimmermann N, Herzig S (1996) PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones. Naunyn Schmiedebergs Arch Pharmacol 354: 424-430 

  • 1995

    1.      Jakob H, Sigmund M, Eschenhagen T, Mende U, Patten M, Schmitz W, Scholz H, Schulte am Esch J, Steinfath M, Hanrath P, Völker H (1995) Effect of captopril on myocardial ß-adrenoceptor density and Gia -proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy. Eur J Clin Pharmacol 47: 389-394

    2.      Eschenhagen T, Diederich M, Kluge SH, Magnussen O, Mende U, Müller F, Schmitz W, Scholz H, Weil J, Sent U, Schaad A, Scholtysik G, Wüthrich A, Gaillard C (1995) Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy. J Mol Cell Cardiol 27: 357-370

    3.      Von der Leyen H, Mügge A, Heublein B, Hecht A, Schmitz W, Scholz H, Wahlers Th, Lichtlen PR (1995) Usefulness of increased myocardial cyclic adenosine 3`,5`- monophosphate content as a sign of rejection after cardiac transplantation. Am J Cardiol 75: 703-706

    4.      Zimmermann N, Bodor GS, Bokník P, Gams E, Jones LR, Neumann J, Scholz H (1995) Mechanisms of the contractile effects of flosequinoxan. Naunyn-Schmiedeberg`s Arch Pharmacol 351: 385-390

    5.      Zhao B, Dierichs R, Harrach-Ruprecht B, Winterhoff H (1995) Oxidized LDL induces serotonin release from blood platelets. Am J Hematol 48: 285-287

    6.      Neumann J, Bokník P, Schmitz W, Scholz H, Zimmermann N (1995) Comparison of the stereoselective effects of a thiadiazinone derivative on contractile parameters and protein phosphorylation in the mammalian ventricle.  J Cardiovasc Pharmacol 25: 789-793

    7.      Neumann J, Bokník P, Kaspareit G, Bartel S, Krause EG, Pask HT, Schmitz W, Scholz H (1995) Effects of the phosphatase inhibitor calyculin A on the phosphorylation of C-protein in mammalian ventricular cardiomyocytes. Biochem Pharmacol 49: 1583-1588

    8.      Vahlensieck U, Hahn R, Winterhoff H, Gumbinger HG, Nahrstedt A, Kemper FH (1995) The effect of chelidonium majus herb extract on choleresis in the isolated perfused rat liver. Planta Med 61: 267-270

    9.      Neumann J, Herzig S, Bokník P, Apel M, Kaspareit G, Schmitz W, Scholz H, Tepel M, Zimmermann N (1995) On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor. J Pharmacol Exp Ther 274: 530-539

    10.    Bethke Th, Klimkiewicz A, Meyer W, Schumacher C, Schmitz W, Scholz H, Starbatty J, Wenzlaff H, Zimmermann W (1995) Characterization of the phosphodiesterase inhibition by 2-(3-methoxy-5-methylsulfinyl-2-thienyl)-1 H-imidazo-(4,5-c)-pyridine HCl and its sulfide- and sulfone derivatives in myocardial preparations from failing human hearts. Arzneimittel-Forschung 45: 771 -776

    11.    Neumann J, Gupta RC, Jones LR, Bodor GS, Bartel S, Krause EG, Pask HT, Schmitz W, Scholz H, Watanabe AM (1995) Interaction of ß-adrenoceptor and adenosine agonists on phosphorylation. Identification of target proteins in mammalian ventricles. J Mol Cell Cardiol 27: 1655-1667

    12.    Lüß H, Watkins SC, Freeswick PD, Imro AK, Nussler AK, Billiar TR, Simmons RL, del Nido PJ, McGowan FX (1995) Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro. J Mol Cell Cardiol 27: 2015-2029

    13.    Weischer ML, Hano R (1995) Einfluß von Noradrenalin- und Dopamin-Agonisten und -Antagonisten auf den Sauerstoffverbrauch einiger Insekten- und Crustaceen - Arten. Arzneimittel-Forschung 45: 1032-1035

    14.    Müller FU, Bokník P, Horst A, Knapp J, Linck B, Schmitz W, Vahlensieck U, Böhm M, Deng MC, Scheld HH (1995) cAMP response element binding protein is expressed and phosphorylated in the human heart.Circulation 92: 2041-2043

    15.    Winterhoff H, Butterweck V, Nahrstedt A, Gumbinger HG, Schulz V, Erping S, Boßhammer F, Wieligmann A (1995) Pharmakologische Untersuchungen zur antidepressiven Wirkung von Hypericum perforatum L. In: Loew D, Rietbrock N, (eds) .Phytopharmaka in Forschung und klinischer Anwendung. Steinkopff Verlag, Darmstadt, pp 39-56.

    16.    Eschenhagen T, Laufs U, Schmitz W, Scholz H, Warnholtz A, Weil J, Schäfer HJ (1995) Enrichment of G Protein a-subunit mRNAS in the AV-conducting system of the mammalian heart. J Mol Cell Cardiol 27: 2249-2263

    17.    Müller FU, Bokník P, Horst A, Knapp J, Linck B, Schmitz W, Vahlensieck U, Walter A (1995) In vivo isoproterenol treatment leads to downregulation of the mRNA encoding the cAMP response element binding protein in the rat heart. Biochem Biophys Res Commun 215: 1043-104

    18.    Stein B, Bartel S, Kokott S, Krause EG, Schlichtmann Th, Schmitz W, Scholz H (1995) Effects of isoprenaline on force of contraction, cAMP content, and phosphorylation of regulatory protein in hearts from chronic ß-adrenergic-stimulated rats. Ann NY Acad Sci 752: 230-233

    19.    Vahlensieck W, Vahlensieck M, Vahlensieck U, Vahlensieck D, Vahlensieck A (1995) Aktueller Stand des Einsatzes jodhaltiger Kontrastmittel in der Urologie. Urologe B 35: 240-247

    20.    Neumann J, Kaspareit G, Kirchhefer U, Scholz H (1995) Sodium fluoride attenuates the negative inotropic effects of muscarinic M2 and adenosine receptor agonists. Eur J Pharmacol 294: 451 – 457

    21.    Wojciechowski H, Gumbinger HG, Vahlensieck U, Winterhoff H, Narstedt A, Kemper FH (1995) Analysis of the components of lycopus europaeus L. in body fluids during metabolism studies. Comparison of capillary electrophoresis and high-performance liquid chromatography. J Chromatogr A 717: 261-270

    22.    Herzig S, Meier A, Pfeiffer M, Neumann J (1995) Stimulation of protein phosphatases as a mechanism of the muscarinic receptor-mediated inhibition of cardiac L-type calcium channels. Pflug Arch Eur J Phy 429: 531-538 

  • 1994

    1.      Stein B, Schmitz W, Scholz H, Seeland C (1994) Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.  J Mol Cell Cardiol 26: 403-414

    2.      Winterhoff H, Gumbinger HG, Vahlensieck U, Kemper FH, Schmitz H, Behnke B (1994) Endocrine effects of lycopus europaeus L. following oral application. Arzneimittel-Forschung 44: 41-45

    3.      Jekat FW,  Meisel ML,  Eckard R,  Winterhoff H (1994) Effects of pentachlorophenol (PCP) on the pituitary and thyroidal hormone regulation in the rat. Toxicol Lett 71: 9-25

    4.      Gupta RC, Neumann J, Boknik P, Watanabe AM (1994) M2-specific muscarinic cholinergic receptor-mediated inhibition of cardiac regulatory protein phosphorylation.  Am J Physiol 266: H1138-H1144

    5.      Böhm M, Eschenhagen T, Gierschik P, Larisch K, Lensche H, Mende U, Schmitz W, Schnabel P, Scholz H, Steinfath M, Erdmann E (1994) Radioimmunochemical quantification of Gia in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. J Mol Cell Cardiol 26: 133-149

    6.      Neumann J, Bokník P, Bodor GS, Jones LR, Schmitz W, Scholz H (1994) Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin. J Pharmacol Exp Ther 269: 1310-1318

    7.      Müller FU, Eschenhagen T, Reidemeister A, Schmitz W, Scholz H (1994 ) In vivo ß-adrenergic stimulation leads to biphasic regulation of Gia-2 gene transcriptional activity in rat heart. J Mol Cell Cardiol 26: 869-875

    8.      Michel MC, Knapp J, Ratjen H (1994) Sensitization by dexamethasone of lymphocyte cyclic AMP formation: evidence for increased function of the adenylyl cyclase catalyst. Br J Pharmacol 113: 240-246

    9.      Weischer ML, Okpanyi SN (1994) Pharmakologie eines pflanzlichen Schlafmittels. Zeitschrift für Phytotherapie 15: 257-262

    10.    Neumann J, Bokník P, Herzig S, Schmitz W, Scholz H, Wiechen K, Zimmermann N (1994) Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor. J Pharmacol Exp Ther 271: 535-541

    11.    Winterhoff H (1994) Toxicological aspects of phytomedicines. European Phytotelegram 6: 17-20

    12.    Wagner H, Nörr H, Winterhoff H (1994) Plant adaptogens. Phytomedicine 1: 63-76

    13.    Zimmermann N, Gams E, Neumann J, Bokník P, Scholz H (1994) Effects of cyclosporine on protein phosphorylation in the heart. Transplant Proc 26: 2875-2876

    14.    Schmitz W, Boknik P, Knapp J, Linck B, Müller FU, Vahlensieck U (1994) Pharmakotherapie nach Herztransplantation. Tx Med 6: 287-290

    15.    Winde G, Mellin W, Schmid W, Schlegel W, Gumbinger HG, Fischer R, Osswald H (1994) Reversion von Rektumadenomen nach Kolektomie mit ileorektaler Anastomose durch eine nicht-steroidale anti-inflammatorische Substanz bei familiärer adenomatöser Polyposis (FAP).In: Häring R (ed) Krebsrisikoerkrankungen des Verdauungstraktes. Blackwell Wissenschafts-Verlag, Berlin, pp 330-367.  

  • 1993

    1.      Winterhoff H, Hambrügge M, Vahlensieck U (1993) Testung von Hypericum perforatum L. im Tierexperiment. Nervenheilkunde 12: 341-345

    2.      Meisel ML, Winterhoff H, Jekat FW (1993) Tylosin inhibits the steroidogenesis in mouse leydig cells ”in vitro”. Life Sci 53: 77-84

    3.      Meisel ML, Winterhoff H, Jekat FW (1993) Effects of tylosin on the pituitary-gonadal axis in male rats. Pharmacol Toxicol 72: 336-340

    4.      Winterhoff H, Gumbinger HG, Vahlensieck U, Streuer M, Nörr H, Wagner H (1993) Effects of eleutherococcus senticosus on the pituitary-adrenal system of rats. Pharm Pharmacol Lett 3: 95-98

    5.      Winterhoff H, Meisel ML, Vahlensieck U, Nörr H, Wagner H (1993) Interference of eleutherococcuss senticosus extract with LHRH and LH stimulation (”in vitro”).  Pharm Pharmacol Lett 3: 99-102

    6.      Winterhoff H (1993) Arzneipflanzen mit endokriner Wirksamkeit. Auswirkungen auf Schilddrüsen- und Ovarfunktion. Zeitschrift für Phytotherapie 14: 83-94

    7.      Gumbinger HG, Vahlensieck U, Winterhoff H (1993) Metabolism of caffeic acid in the isolated perfused rat liver. Planta Med 59: 491-493

    8.      Müller FU, Boheler KR, Eschenhagen T, Schmitz W, Scholz H (1993) Isoprenaline stimulates gene transcription of the inhibitory G protein a-subunit Gia-2 in rat heart. Circ Res 72: 696-700

    9.      Neumann J, Boknik P, Herzig S, Schmitz W, Scholz H, Gupta RC, Watanabe AM (1993) Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid. Am J Physiol 265: H257-H266

    10.    Veit M, Gumbinger HG (1993) Hydroxyzimtsäuren und Derivate. Pflanzeninhaltstoffe an der Nahtstelle zwischen Primär- und Sekundärstoffwechsel. Deutscher Apotheker Zeitung 133: 911-931

    11.    Von Schrenck T, Mackensen B, Mende U, Schmitz W, Sievers J, Mirau S, Raedler A, Greten H (1993) Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction. Naunyn-Schmiedeberg`s Arch Pharmacol 349: 346-354

    12.    John M, Gumbinger HG, Winterhoff H (1993) The oxidation of caffeic acid derivates as model reaction for the formation of potent gonadotropin inhibitors in plant extracts. Planta Med 59: 195-199

    13.    Winde G, Gumbinger HG, Osswald H, Kemper F, Bünte H (1993) The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adematous polyposis: clinical results of a dose-finding study on rectal sulindac administration.  Int J Colorectal Dis 8: 13-17 

  • 2020

    1. Heinick, Alexander; Pluteanu, Florentina; Hermes, Christina; Klemme, Andre; Domnik, Manuel; Husser, Xenia et al. (2020): Annexin A4 N-terminal peptide inhibits adenylyl cyclase 5 and limits ß-adrenoceptor-mediated prolongation of cardiac action potential. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology. DOI: 10.1096/fj.201902094RR.

    2. Seidl, Matthias D.; Fels, Benedikt; Kranick, Daniel; Sternberg, Alexandra; Grimm, Kristina; Stümpel, Frank T. et al. (2020): Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology. DOI: 10.1096/fj.201902301RR.