Publikationen

2023

Goretzko J, Pauels I, Heitzig N, Thomas K, Kardell M, Naß J, Krogsaeter EK, Schloer S, Spix B, Linard Matos AL, Leser C, Wegner T, Glorius F, Bracher F, Gerke V, Rossaint J, Grimm C, Rescher U.

P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2. Cell Rep. 42:113501. doi: 10.1016/j.celrep.2023.113501.

Vöing K, Michgehl U, Mertens ND, Picciotto C, Maywald ML, Goretzko J, Waimann S, Gilhaus K, Rogg M, Schell C, Klingauf J, Tsytsyura Y, Hansen U, van Marck V, Edinger AL, Vollenbröker B, Rescher U, Braun DA, George B, Weide T, Pavenstädt H.

Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. J Am Soc Nephrol. 34:1191-1206. doi: 10.1681/ASN.0000000000000126.

Kroll MK, Schloer S, Candan P, Korthals N, Wenzel C, Ihle H, Gilhaus K, Liedtke KR, Schöfbänker M, Surmann B, Schröter R, Neugebauer U, Mall G, Oswald S, Ludwig S, Rescher U, Vollenbröker B, Ciarimboli G.

Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells. Biomolecules 13:472. doi: 10.3390/biom13030472

Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L.

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier. Antiviral Res. 209:105475. doi: 10.1016/j.antiviral.2022.105475.

Rohrbeck M, Hoerr V, Piccini I, Greber B, Schulte JS, Hübner SS, Jeworutzki E,Theiss C, Matschke V, Stypmann J, Unger A, Ho HT, Disse P, Strutz-Seebohm N, Faber C, Müller FU, Ludwig S, Rescher U, Linke WA, Klingel K, Busch K, Peischard S, Seebohm G.

Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis. Cells.12:550. doi: 10.3390/cells12040550.

2022

Schloer S, Treuherz D, Faist A, de Witt M, Wunderlich K, Wiewrodt R, Wiebe K, Barth P, Wälzlein JH, Kummer S, Balkema-Buschmann A, Ludwig S, Brunotte L, Rescher U.

3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseases. Emerg Microbes Infect. 2022 Dec;11(1):2160-2175. doi: 10.1080/22221751.2022.2117101.PMID: 36000328

Schreiber A, Ambrosy B, Planz O, Schloer S, Rescher U, Ludwig S.

The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs.Pharmaceutics. 2022 Aug 25;14(9):1776. doi: 10.3390/pharmaceutics14091776.PMID: 36145524

Schloer S, Goretzko J, Rescher U.

Repurposing Antifungals for Host-Directed Antiviral Therapy?

Pharmaceuticals (Basel). 2022 Feb 10;15(2):212. doi: 10.3390/ph15020212.

Schreiber A, Viemann D, Schöning J, Schloer S, Mecate Zambrano A, Brunotte L, Faist A, Schöfbänker M, Hrincius E, Hoffmann H, Hoffmann M, Pöhlmann S, Rescher U, Planz O, Ludwig S.

The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses.

Cell Mol Life Sci. 2022 Jan 10;79(1):65. doi: 10.1007/s00018-021-04085-1.

Kummer S, Lander A, Goretzko J, Kirchoff N, Rescher U, Schloer S.Brunotte L, Zheng S, Mecate-Zambrano A, Tang J, Ludwig S, Rescher U, Schloer S.

Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro.

Emerg Microbes Infect. 2022 Dec;11(1):195-207. doi: 10.1080/22221751.2021.2020598.

Ehring K, Manikowski D, Goretzko J, Froese J, Gude F, Jakobs P, Rescher U, Kirchhefer U, Grobe K.

Conserved cholesterol-related activities of Dispatched 1 drive Sonic Hedgehog shedding from the cell membrane.

J Cell Sci. 2022 Mar 1;135(5):jcs258672. doi: 10.1242/jcs.258672. PMID: 34308968

2021

Brunotte L, Zheng S, Mecate-Zambrano A, Tang J, Ludwig S, Rescher U, Schloer S.

Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro.

Pharmaceutics. 2021 Sep 3;13(9):1400.doi:10.3390/pharmaceutics13091400.

Schloer S, Brunotte L, Mecate-Zambrano A, Zheng S, Tang J, Ludwig S, Rescher U.
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro.

Br J Pharmacol. 2021 Jun;178(11):2339-2350. doi: 10.1111/bph.15418.

Raabe CA, Rescher U.

Can you teach an old receptor new tricks?

J Leukoc Biol. 2021 Aug;110(2):217-218. doi: 10.1002/JLB.2CE0920-568R.

Gerke V, Rescher U.

ANO5 in membrane repair - Status: "It's complicated"

Cell Calcium. 2021 Apr 27;97:102415. doi: 10.1016/j.ceca.2021.102415

Grewal T, Rentero C, Enrich C, Wahba M, Raabe CA, Rescher U.

Annexin Animal Models-From Fundamental Principles to Translational Research.

Int J Mol Sci. 2021 Mar 26;22(7):3439. doi:0.3390/ijms22073439.

2020

Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U.

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine.

Emerg Microbes Infect. 2020Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082.

Rescher U, Gerke V, Lim LHK, Jaiswal JK.
Special Issue: Recent Developments in Annexin Biology.
Cells. 2020; 14;9(11):2477. doi: 10.3390/cells9112477.

Schlesier T, Siegmund A, Rescher U, Heilmann C.
Characterization of the Atl-mediated staphylococcal internalization mechanism.
Int J Med Microbiol. 2020 Dec;310(8):151463.

Schloer S, Goretzko J, Pleschka S, Ludwig S, Rescher U.
Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection.
Viruses. 2020 Jun 29;12(7):E703.

Gröper J, König GM, Kostenis E, Gerke V, Raabe CA, Rescher U.
Exploring biased agonism at FPR1 as a means to encode danger sensing.
Cells. 2020 Apr 23;9(4). pii: E1054. doi: 10.3390/cells9041054

Boltersdorf T, Ansari J, Senchenkova EY, Groeper J, Pajonczyk D, Vital SA, Kaur G, Alexander JS, Vogl T, Rescher U, Long NJ, Gavins FNE.
Targeting of Formyl Peptide Receptor 2 for in vivo imaging of acute vascular inflammation.
Theranostics. 2020; 10(15): 6599-6614. doi: 10.7150/thno.44226

2019

Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L.
Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
Emerg Microbes Infect. 2019;8(1):1763-1776. doi: 10.1080/22221751.2019.1698271.

Herzog S, Dach F, de Buhr N, Niemann S, Schlagowski J, Chaves-Moreno D, Neumann C, Goretzko J, Schwierzeck V, Mellmann A, Dübbers A, Küster P, Schültingkemper H, Rescher U, Pieper DH, von Köckritz-Blickwede M, Kahl BC.
High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing.
Front Immunol. 2019 Nov 5;10:2552. doi: 10.3389/fimmu.2019.02552. eCollection 2019.

Schloer S, Hübel N, Masemann D, Pajonczyk D, Brunotte L, Ehrhardt C, Brandenburg LO, Ludwig S, Gerke V, Rescher U.
The annexin A1/FPR2 signaling axis expands alveolar macrophages, limits viral replication, and attenuates pathogenesis in the murine influenza A virus infection model.
FASEB J. 2019 Nov;33(11):12188-12199. doi: 10.1096/fj.201901265R. Epub 2019 Oct 2.
PMID: 31398292

Raabe CA, Gröper J, Rescher U.
Biased perspecives on formyl peptide receptors
Biochim Biophys Acta Mol Cell Res 2019;1866(2):305
316.doi:10.1016/j.bbamcr.2018.11.015. Epub Dec 4, Review.
PMID29914106

Schloer, Sebastian; Goretzko, Jonas; Kuehnl, Alexander; et al.
The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo
EMERGING MICROBES & INFECTIONS Volume: 8 Issue: 1 Pages: 80-93 Published: JAN 16 2019

2018

Krischuns T, Günl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L.
Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.
Front Immunol. 2018 Sep 28;9:2229. doi: 10.3389/fimmu.2018.02229. eCollection 2018.

Schloer S, Pajonczyk D, Rescher U.
Annexins in Translational Research: Hidden Treasures to Be Found.
Int J Mol Sci. 2018 Jun 15;19(6). pii: E1781. doi: 10.3390/ijms19061781. Review.

Matos ALL, Grill D, Kudruk S, Heitzig N, Galla HJ, Gerke V, Rescher U.
Dissipative Microgravimetry to Study the Binding Dynamics oft he Pospholipid Binding Protein Annexin A2 to Solid-supported Lipid Bilayers Using a Quartz Resonator
J Vis Exp 2018 Nov 1; (141). Doi: 10.3791/58224
PMID:30451221

Kühnl A, Musiol A, Heitzig N, Johnson DE, Ehrhardt C, Grewal T, Gerke V, Ludwig S, Rescher U
Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibitin Endosomal Escape of Influenza A Virus
MBio 2018 Jul 24;9(4). Pii: e01345-18. doi: 10.1128/mBio.01345-18
PMID: 30042202

Heitzig N, Kühnl A., Grill D, Ludewig K, Schloer S, Galla HJ, Grewal T, Gerke V, Rescher U
Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.
Biochim Biophys Acta. 2018 Apr;1863(4):349-358. doi: 10.1016/j.bbalip.2018.01.001. [Epub 2018 Jan 3]
PMID: 290306076

2017

Heitzig N, Kühnl A, Grill D, Ludewig K, Schloer S, Galla HJ, Grewal T, Gerke V, Rescher U.
Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes.
Biochim Biophys Acta -Mol Cell Biol Lipids. 2018 Jan 3. pii: S1388-1981(18)30002-7. doi: 10.1016/j.bbalip.2018.01.001.

Lueck K, Carr AF, Stampoulis D, Gerke V, Rescher U, Greenwood J, Moss SE.
Regulation of retinal pigment epithelial cell phenotype by Annexin A8.
Sci Rep. 2017 Jul 5;7(1):4638. doi: 10.1038/s41598-017-03493-3. PMID: 28680125, Free PMC Article

Schulze U, Vollenbröker B, Kühnl A, Granado D, Bayraktar S, Rescher U, Pavenstädt H, Weide T.
Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase.
Biochim Biophys Acta. 2017 May;1864(5):749-759. doi: 10.1016/j.bbamcr.2017.02.012. Epub 2017 Feb 16., PMID: 28216340

Heitzig N, Brinkmann BF, Koerdt SN, Rosso G, Shahin V, Rescher U.
Annexin A8 promotes VEGF-A driven endothelial cell sprouting.
Cell Adh Migr. 2017 May 4;11(3):275-287. doi: 10.1080/19336918.2016.1264559. Epub 2017 Jan 6.

2016

Rescher U, Grewal T.
Highlight: annexins in health and disease
Biol Chem. 2016 Oct 1;397(10):947-8. doi: 10.1515/hsz-2016-0264. No abstract available.

Kuehnl A, Musiol A, Raabe CA, Rescher U.
Emerging functions as host cell factors - an encyclopedia of annexin-pathogen interactions.
Biol Chem. 2016 Oct 1;397(10):949-59. doi: 10.1515/hsz-2016-0183.

2014

Quiskamp N, Poeter M, Raabe CA, Hohenester UM, König S, Gerke V, Rescher U
The tumor suppressor annexin A10 is a novel component of nuclear paraspeckles.
Cell Mol Life Sci. 2014 Volume 71(2):311-29 JAN 2014

Poeter M, Brandherm I, Rossaint J, Rosso G, Shahin V, Skryabin BV, Zabock A, Gerke V, Rescher U
Annexin A8 controls leucocyte recruitment to activated endothelial cells via cells surface delivery of CD63.
Nature Commun 5: 3738. APR 2014

Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U
Annexin A6-balanced late endosomal cholesterol controls Influenza A replication and propagation.
MBio 4(6): e00608-13. [doi: 10.1128/ mBio. 00608-13]

2013

Duning K, Wennmann DO, Bokemeyer A, Reissner C, Wersching H, Thomas C, Buschert J, Guske K, Franzke V, Flöel A, Lohmann H, Knecht S, Brand SM, Pöter M, Rescher U, Missler M, Seelheim P, Pröpper C, Boeckers TM, Makuch L, Huganir R, Weide T, Brand E, Pavenstädt H, Kremerskothen J.
Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance.
Transl Psychiatry. 2013 Jun 18;3:e272. doi: 10.1038/tp.2013.49.

2012

Poeter M, Radke S, Koese M, Hessner F, Hegemann A, Musiol A, Gerke V, Grewal T, Rescher U.
Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling.
Biochim. Biophys. Acta. 2012 Dec 14. doi:pii: S0167-4889(12)00369-2.

Ibrahim SA, Yip GW, Stock C, Pan JW, Neubauer C, Poeter M, Pupjalis D, Koo CY, Kelsch R, Schüle R, Rescher U, Kiesel L, Götte M.
Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism.
Int. J. Cancer. 2012 131(6):E884-96.

2010

Danute Pupjalis, Julia Goetsch, Diane J. Kottas, Volker Gerke and Ursula Rescher
Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signaling
Accepted manuscript online: 17 DEC 2010 08:56AM EST | DOI: 10.1002/emmm.201000113

Eierhoff T, Hrincius ER, Rescher U, Ludwig S, Ehrhardt C.
The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
PLoS Pathog. 2010 Sep 9;6(9). pii: e1001099.

Backes P, Quinkert D, Reiss S, Binder M, Zayas M, Rescher U, Gerke V, Bartenschlager R, Lohmann V.
Role of annexin A2 in the production of infectious hepatitis C virus particles.
J Virol. 2010 Jun;84(11):5775-89. Epub 2010 Mar 24.

2008

Goebeler V, Poeter M, Zeuschner D, Gerke V, Rescher U.
Annexin A8 Regulates Late Endosome Organization and Function.
Mol Biol Cell. 2008 Dec;19(12):5267-78. Epub 2008 Oct 15.

Rescher U, Ludwig C, Konietzko V, Kharitonenkov A, Gerke V.
Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion.
J Cell Sci. 2008 Jul 1;121(Pt 13):2177-85.

van de Graaf SF, Rescher U, Hoenderop JG, Verkaart S, Bindels RJ, Gerke V.
TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway.
J. Biol. Chem. 283, 4077-4086

Rescher U, Gerke V. (2008)
S100A10/p11: family, friends and functions.
Arch. 455, 575-582

2007

Lange C, Starrett D, Goetsch J, Gerke V, Rescher U. (2007)
Transcriptional profiling of human monocytes reveals complex changes in the expression pattern of inflammation-related genes in response to the annexin A1 derived peptide Ac1-25J.
Leukoc. Biol. 82, 1592-1604

Monastyrskaya K, Babiychuk EB, Hostettler A, Rescher U, Draeger A.
Annexins as intracellular calcium sensors.
Cell Calcium. 2007 Mar;41(3):207-19.

Maier SM, Scherer SJ, Seifert M, Hanselmann RG, Schleehuber Y, Edelmann L, Reichrath J, Krohne G, Rescher U, Seidl W, Mutschler W, Claes L, Welter C, Schartl M.
1[alpha],25-dihydroxyvitamin D(3) enhances annexin II dependent proliferation of osteoblasts.
J Cell Biochem. 2007 Feb 15;100(3):679-92.

Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K.
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.
Cell. 2007 Jan 26;128(2):383-97.

2006

Rescher U, Goebeler V, Wilbers A, Gerke V.
Proteolytic cleavage of annexin 1 by human leukocyte elastase.
Biochim Biophys Acta. 2006 Nov;1763(11):1320-4. Epub 2006 Sep 1.

McNeil AK, Rescher U, Gerke V, McNeil PL.
Requirement for annexin A1 in plasma membrane repair.
J Biol Chem. 2006 Nov 17;281(46):35202-7. Epub 2006 Sep 19.

Tatenhorst L, Rescher U, Gerke V, Paulus W.
Knockdown of annexin 2 decreases migration of human glioma cells in vitro.
Neuropathol Appl Neurobiol. 2006 Jun;32(3):271-7.

Goebeler V, Ruhe D, Gerke V, Rescher U.
Annexin A8 displays unique phospholipid and F-actin binding properties.
FEBS Lett. 2006 May 1;580(10):2430-4. Epub 2006 Apr 7.

2004

Radke S, Austermann J, Russo-Marie F, Gerke V, Rescher U.
Specific association of annexin 1 with plasma membrane-resident and internalized EGF receptors mediated through the protein core domain.
FEBS Lett. 2004 Dec 3;578(1-2):95-8.

Rescher U, Ruhe D, Ludwig C, Zobiack N, Gerke V.
Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes.
J Cell Sci. 2004 Jul 15;117(Pt 16):3473-80. Epub 2004 Jun 29.

Ernst S, Zobiack N, Boecker K, Gerke V, Rescher U.
Agonist-induced trafficking of the low-affinity formyl peptide receptor FPRL1.
Cell Mol Life Sci. 2004 Jul;61(13):1684-92.

Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U.
An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.
J Immunol. 2004 Jun 15;172(12):7669-76.

Rescher U, Gerke V.
Annexins--unique membrane binding proteins with diverse functions.
J Cell Sci. 2004 Jun 1;117(Pt 13):2631-9. Review.

2003

Monastyrskaya K, Babiychuk EB, Schittny JC, Rescher U, Gerke V, Mannherz HG, Draeger A.
The expression levels of three raft-associated molecules in cultivated vascular cells are dependent on culture conditions.
Cell Mol Life Sci. 2003 Dec;60(12):2702-9.

Jacob R, Heine M, Eikemeyer J, Frerker N, Zimmer KP, Rescher U, Gerke V, Naim HY.
Annexin II is required for apical transport in polarized epithelial cells.
J Biol Chem. 2004 Jan 30;279(5):3680-4. Epub 2003 Dec 11.

Zobiack N, Rescher U, Ludwig C, Zeuschner D, Gerke V.
The annexin 2/S100A10 complex controls the distribution of transferrin receptor-containing recycling endosomes.
Mol Biol Cell. 2003 Dec;14(12):4896-908. Epub 2003 Sep 17.

Goebeler V, Ruhe D, Gerke V, Rescher U.
Atypical properties displayed by annexin A9, a novel member of the annexin family of Ca(2+) and lipid binding proteins.
FEBS Lett. 2003 Jul 10;546(2-3):359-64.

van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ.
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.
EMBO J. 2003 Apr 1;22(7):1478-87.

2002

Rescher U, Danielczyk A, Markoff A, Gerke V.
Functional activation of the formyl peptide receptor by a new endogenous ligand in human lung A549 cells.
J Immunol. 2002 Aug 1;169(3):1500-4.

2001

Zobiack N, Rescher U, Laarmann S, Michgehl S, Schmidt MA, Gerke V.
Cell-surface attachment of pedestal-forming enteropathogenic E. coli induces a clustering of raft components and a recruitment of annexin 2.
J Cell Sci. 2002 Jan 1;115(Pt 1):91-8.

Merrifield CJ, Rescher U, Almers W, Proust J, Gerke V, Sechi AS, Moss SE.
Annexin 2 has an essential role in actin-based macropinocytic rocketing.
Curr Biol. 2001 Jul 24;11(14):1136-41.

Zobiack N, Gerke V, Rescher U.
Complex formation and submembranous localization of annexin 2 and S100A10 in live HepG2 cells.
FEBS Lett. 2001 Jul 6;500(3):137-40.

2000

Rescher U, Zobiack N, Gerke V.
Intact Ca(2+)-binding sites are required for targeting of annexin 1 to endosomal membranes in living HeLa cells.
J Cell Sci. 2000 Nov;113 ( Pt 22):3931-8.