Identification and functional analysis of barrier-breaking genes in myeloid cells Genes and mechanisms that determine the invasive potential of myeloid and myelo-monocytic cells remain incompletely understood. In this project, we will systematically identify and characterize genes and functional mechanisms that determine the invasiveness of myeloid cells with a focus on myeloid leukemia blasts. S100P functions in myeloid invasiveness will be analyzed in detail along with genes identified in a shRNA library screen. Functional analyses in mouse models will determine the relevance for overcoming natural barriers for myeloid cells in vivo.
Publications
Original articles
Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, Bäumer S, Berdel WE, Müller-Tidow C, Tickenbrock L (2014) Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions. PLoS One 9 (4): e94993. [doi: 10.1371/journal.pone.0094993. eCollection 2014]
Reviews
Schoofs T, Berdel WE, Mü̈ller-Tidow C (2014) Origins of aberrant DNA methylation in acute myeloid leukemia. Leukemia 28: 1–14.
