Project area A
Project area A: Integrity and cellular penetration of barriers
Leukocyte diapedesis through the blood vessel wall and mechanisms that modulate integrin activation
Funding period: 07.2012 - 06.2024
Mechanisms of leukocyte penetration of vascular cell basement membranes
Funding period: 07.2012 - 06.2024
Immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier: Mechanisms and consequences
Prof. Dr. Luisa Klotz (since 07/2016); Prof. Dr. Heinz Wiendl
Funding period: 07.2012 - 06.2024
Analysis of the Drosophila blood brain barrier
Prof. Dr. Christian Klämbt; Prof. Dr. Stefan Luschnig (since 07/2016); Dr. Stefanie Schirmeier (since 07/2016)
Funding period: 07.2012 - 06.2024
The role of GTPases in integrin activation and leukocyte recruitment
Funding period: 07.2012 - 06.2024
Formyl peptide chemoattractant receptors in leukocyte activation and trans-endothelial migration
Prof. Dr. Ursula Rescher; Prof. Dr. Volker Gerke
Funding period: 07.2012 - 06.2024
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Interplay of integrin-mediated adhension and MMP14-driven proteolysis in matrix barrier-breaking invadopodia of tumour cells
Funding period: 01.2014 - 06.2024
Regulation of blood-brain-barrier function by pericytes
Funding period: 07.2016 - 06.2024
Interaction of macrophages with cell matrix niches in lymphoid organs
Funding period: 07.2020 - 06.2024
A13 Neutrophils regulate endothelial dysfunction in atherosclerosis
Funding period: 07.2021 - 06.2024
Project area B
Project area B: Cellular barriers as target for infection and immune processes
The role of MAPK in influenza virus (IV) replication and bacterial super-infection
Prof. Dr. Christina Ehrhardt (till 06/2020); Prof. Dr. Stephan Ludwig; Dr. Yvonne Börgeling (since 07/2020)
Funding period: 07.2012 - 06.2020
Autopenetrating bacterial effector proteins and modulation of signaling responses in cellular barriers
PD Dr. Christian Rüter (since 07/2016); Prof. Dr. M. Alexander Schmidt
Funding period: 07.2012 - 06.2020
The bacterial secreted combinome: Synergistic host injury by exotoxins of enterohemorrhagic Escherichia coli
Funding period: 07.2012 - 06.2020
Genetic basis involved in host interaction and adaptation of Escherichia coli: Impact on crosstalk with cellular barriers
Funding period: 07.2012 - 06.2020
The role of RANK/RANKL signaling for skin homeostasis and barrier function during anti-microbial immune responses
Funding period: 07.2012 - 06.2020
DAMP-induced proinflammatory feedback mechanisms between phagocytes and endothelial / epithelial barriers in infectious diseases
Funding period: 07.2012 - 06.2020
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Epidermal stress response and barrier integrity in allergy and autoimmune diseases
Funding period: 07.2012 - 06.2020
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The role of calcium mediated actin rearrangement (CaAR) in podocyte function
Prof. Dr. Roland Wedlich-Söldner, Prof. Dr. Hermann Pavenstädt
Funding period: 06.2016 - 06.2020
B 11 Impact on innate immune signals on hapten-specific immune responses
Funding period: 07.2020 - 06.2024
B 12 Roles of the CNFY toxin for Yersinia pseudotuberculosis for crossing intestinal barriers, colonization of subepithelial tissue and pathology
Prof. Dr. Petra DerschProjektlaufzeit: 07.2020 - 06.2024
B 13 The role of MAPK pathways in SARS CoV-2 infection and COVID-19 disease
Prof. Dr. rer. nat. Stephan Ludwig
Funding Period: 07.2020 - 06.2024
Project area Z
Project area Z: Central projects
Management / Public Relations
Prof. Dr. Johannes Roth (since 06/2016)
Funding period: 07.2012 - 06.2020
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Non-invasive imaging, cell tracking and functional analyses at cellular barriers
Prof. Dr. Cornelius Faber; Prof. Dr. Johannes Roth (since 06/2016); Prof. Dr. Karin Loser (since 06/2016)
Funding period: 07.2012 - 06.2020
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Structured training programms "Experimental Medicine" and "MedK"
Prof. Dr. Rupert Hallmann; Prof. Dr. Dr. h. c. Helge Karch
Funding period: 07.2016 - 06.2020
Completed Projects
Enclosed Projects
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Identification and functional analysis of barrier-breaking genes in myeloid cells
Prof. Dr. med. Carsten Müller-Tidow (Alumni)
Funding period: 07.2012 - 12.2014
Mechanisms of transendothelial fibroblast migration in rheumatoid arthritis
Funding period: 07.2012 - 06.2016
