![](/fileadmin/_processed_/9/e/csm_CROPPED_Cells_in_the_subventricular_zone_of_the_embryonic_brain_c46d72ffa9.png)
© Projekt A10 - R.H. Adams
![](/fileadmin/_processed_/8/7/csm_CROPPED_Embryonic_brain_blood_vessels_around_3rd_ventricle_e548442f8b.png)
© Projekt A10 - R.H. Adams
![](/fileadmin/_processed_/4/7/csm_CROPPED_High_magnification_of_brain_blood_vessel_ca23d3da99.png)
© Projekt A10 - R.H. Aadams
![](/fileadmin/_processed_/e/4/csm_CROPPED_Pial_vessels_in_mouse_brain_cortex_0e24d623a8.png)
© Projekt A10 - R.H. Aadams
![](/fileadmin/_processed_/8/5/csm_CROPPED_Retina_blood_vessels_d82594c2df.png)
© Projekt A10 - R.H. Aadams
The barrier function of the endothelium is critically required for physiological processes in different organs of the healthy organism and, conversely, disruption of the endothelial barrier is a hallmark of many disease processes. Here, we propose to investigate how the transcription factor Yin Yang 1 (YY1), an important regulator of gene expression and chromatin organization, controls EC behavior and endothelial permeability in the central nervous system and in bone in a comparative fashion.
Research area: Endothelial cell biology
Prof. Dr. Ralf Adams
Funding period: July 2016 - June 2024
Original articles