| Partner | Institution | Department | Scientist-in-charge | Project |
|---|---|---|---|---|
| 1 | Westfälische Wilhelms-Universität Münster (WWU), DE http://www.uni-muenster.de/en/ | Institute of Physiology II medizin.uni-muenster.de/physiologieii.html | Albrecht Schwab | Modulation of pressure sensing of pancreatic stellate cells (PSCs) by pancreatic pH. |
| 1 | Westfälische Wilhelms-Universität Münster (WWU), DE http://www.uni-muenster.de/en/ | Institute of Physiology II medizin.uni-muenster.de/physiologieii.html | Verena Hofschröer | Administrator |
| 2 | University of Oxford (UOXF), UK http://www.ox.ac.uk/ | Department of Physiology, Anatomy and Genetics http://www.dpag.ox.ac.uk/ | Pawel Swietach | Modelling and understanding spatio-temporal pH dynamics in PDAC in silico using in vivo and in vitro data. |
| 3 | University of Copenhagen (UCPH), DK http://www.ku.dk | Department of Biology, Cell Biology and Physiology http://www1.bio.ku.dk/ | Ivana Novak Stine F. Pedersen Albin Sandelin | Role of pH and purinergic signaling in normal pancreas and PDAC. Interactions between microenvironmental acidity and PDAC driver mutations studied in 3D organotypic culture. Relation and causality between pH homeostasis and driver mutation generation in PDAC development. |
| 4 | University of Bari (UBa), IT http://www.uniba.it | Department of Biosciences, Biotechnology and Biopharmaceutics /dipartimenti/bioscienze-biotecnologie">https://www.uniba.it/ricerca/dipartimenti/bioscienze-biotecnologie | Stephan J Reshkin | Role of ECM composition and stromal cells in determining tumour and cancer stem cell pH/O2 handling and therapeutic response. |
| 5 | University of Florence (UNIFI), IT https://www.unifi.it/ | Department of Experimental and Clinical Medicine. Section of Internal Medicine https://www.unifi.it/cercachi-str-058513.html | Annarosa Arcangeli | Targeting ion channel and adhesion receptor interaction during PDAC progression by pH-sensitive engineered antibodies. |
| 6 | University of Lille 1 (ULi), FR https://www.univ-lille.fr/ | Laboratory of Cellular Physiology (INSERM U1003) http://phycell.univ-lille.fr/about-us/ | Natalia Prevarskaya | Role of Ca2+ permeable channels in PDAC and PSCs. |
| 7 | University of Picardie Jules Verne (UPJV), FR https://www.u-picardie.fr/ | Laboratory of Cellular and Molecular Physiology https://www.u-picardie.fr/unites-de-recherche/lpcm/ | Halima Ouadid-Ahidouch | Expression profiling of pH-regulatory and -sensitive transportome: epigenetic analysis and correlation with clinical parameters. |
| 8 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG), DE https://www.mpg.de/en | Max-Planck Institute for Experimental Medicine Göttingen ex.php?id=1&L=1">http://www.em.mpg.de/index.php?id=1&L=1 | Luis Pardo Frauke Alves | Simultaneous targeting of tumour cells and stroma by pH-sensitive engineered biologicals. Assessment of physico-chemical parameters of PDAC by non-invasive imaging during tumour progression and in response to therapeutically targeting pH-dependent processes. |
| 9 | Christian-Albrecht-Universität Kiel (CAU), DE www.uni-kiel.de/de/">https://www.uni-kiel.de/de/ | Institute for Experimental Cancer Research http://www.iet.uni-kiel.de/de | Anna Trauzold | Acquired nuclear functions of TRAIL-receptors as a consequence and motor of pH gradient reversal in PDAC. |
| 10 | University of Debrecen (UNIDEB), HU https://unideb.hu/en | Department of Biophysics and Cell Biology https://biophys.med.unideb.hu/en | György Panyi | Ion channels of immune cells and their regulation by the micro- environment in PDAC and its interface with normal tissue. |
| 11 | Percuros B.V. (PERC), NL http://www.percuros.com | "" | Alan Chan | Molecular imaging of the microenvironment-transportome interplay in PDAC. |
| 12 | Heidelberg-Pharma Research GmbH (HDP), DE https://heidelberg-pharma.com/de/ | "" | Andreas Pahl | Generation of PDAC specific ADCs and preclinical profiling. |
| PARTNER ORGANISATIONS | ||||
| 1 | University of Torino (UNITO), IT https://en.unito.it | Department of Life Sciences and Systems Biology https://dbiosen.campusnet.unito.it/do/home.pl | Alessandra Fiorio Pla | |
| 2 | ERASMUS Medical Center Rotterdam (EMC), NL https://www.erasmusmc.nl/ | Department of Radiology https://www.erasmusmc.nl/roar/departments/radiology/ | Clemens Löwik | |
| 3 | University of Padua (UNIPD), IT https://www.unipd.it/ | Department of Biology https://www.biologia.unipd.it/ | Ildiko Szabo | |
| 4 | Georg-August-Universität Göttingen (UGOE), DE http://www.uni-goettingen.de/ | GAUSS https://www.uni-goettingen.de/en/563915.html Institute of Diagnostic and Interventional Radiology | Jonas Barth to:office@gauss.uni-goettingen.de">mail Joanna Napp | |
| 5 | TypeOne Srl (TYPE1), IT http://www.typeone.it/ | Biomaterial Laboratory | Luca Salvatore | |
