Hengxi Zhang, PhD

 

Medical Scientist
E-Mail: Hengxi Zhang

  • University training and degree

    2014 – 2017 M.Sc in Microbiology, Shandong University, China
    2009 – 2013 B.Sc. in Chemical engineering, Shandong University of science and technology, China

  • Scientific career and activities

    2017 – 2022 PhD in Pharmacy and structural Glycobiology, the Freie Universität Berlin, the Max Planck Institute for Colloids and Interfaces, Universität Wien, Germany and Austria, Topic: “identification of allosteric modulators and investigations on the allosteric mechanism of the C-type lectins DC-SIGN and Langerin”

  • Academic memberships and activities

    2024 – Research programme “ReproTrack.MS”, funded by BMBF
    2024 – Postdoctoral scientist, Centre of Reproductive Medicine and Andrology (CeRA), UKM, Germany
    2023 – 2024 Postdoctoral scientist, The Chinese University of Hong Kong (shenzhen), China

  • Selected publications

    1. Zhang H, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA, Lefèbre J, Che K, Kim D, Kagelmacher M, Kurzbach D, Nazaré M, Rademacher C. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chem Biol. 2022 Oct 21;17(10):2728-2733. doi: 10.1021/acschembio.2c00626. Epub 2022 Sep 26.
    2. Zhang H, Daněk O, Makarov D, Rádl S, Kim D, Ledvinka J, Vychodilová K, Hlaváč J, Lefèbre J, Denis M, Rademacher C, Ménová P. Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold. ACS Med Chem Lett. 2022 May 10;13(6):935-942. doi: 10.1021/acsmedchemlett.2c00067.
    3. Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger FF, Zhang H, Modenutti C, Schnirch L, Marti MA, Schwardt O, Bräutigam M, Guberman M, Hauck D, Seeberger PH, Seitz O, Titz A, Ernst B, Rademacher C. A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN. J Am Chem Soc. 2021 Nov 17;143(45):18977-18988. doi: 10.1021/jacs.1c07235. Epub 2021 Nov 8.
    4. Joswig JO, Anders J, Zhang H, Rademacher C, Keller BG. The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin. J Biol Chem. 2021 Jan-Jun;296:100718. doi: 10.1016/j.jbc.2021.100718. Epub 2021 May 12.
    5. Shanina E, Siebs E, Zhang H, Varón Silva D, Joachim I, Titz A, Rademacher C. Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa. Glycobiology. 2021 Feb 9;31(2):159-165. doi: 10.1093/glycob/cwaa057.

    * contributed equally