Bone and tumor biology Group
I completed my PhD at the University of Muenster at Prof Pap´s lab where I investigated the impact of fibroblast-like synoviocytes on bone homeostasis in rheumatoid arthritis (RA). I joined the University of Birmingham/UK in 2016 as a Postdoctoral researcher at the Institute of Inflammation and Ageing working with Prof Chris Buckley´s team and was awarded a DFG research fellowship to investigate the role of podoplanin in RA.
Since 2022 I am a group leader of the Bone & Tumor biology group at the Institute of Musculoskeletal Medicine, University of Muenster. Our research group focus on bone homeostasis in musculoskeletal diseases accompanied with inflammation or metastatic cancer to identify new therapeutic approaches to reverse bone loss. In detail, we are investigating the bone cancer-cell niche exploring the role of osteocyte-, osteoclast- and tumor cell- crosstalk. Moreover, we are interested on the impact of osteocytes and their canalicular network on bone remodeling.
Team
Projects
completed and current third-party funded projects:
Deutsche Forschungsgemeinschaft - DFG WE 6095/4-1
Dr. Corinna Wehmeyer
In der Knochenmatrix eingebettete Osteozyten und ihre regulatorische Funktion bei der Knochenhomölstase während der Rheumatoiden Arthrits
2021-2024Interdisziplinäres Zentrum für Klinische Forschung Münster (IZKF)
Dr. Corinna Wehmeyer,
Impact of osteocyte-cancer cell crosstalk on bone homeostasis in multiple myeloma"
2023-2025Publications
Relevant publications
Waltereit-Kracke V, Wehmeyer C, Beckmann D, Werbenko E, Reinhardt J, Geers F, Dienstbier M, Fennen M, Intemann J, Paruzel P, Korb-Pap A, Pap A, Dankbar B
Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis.
Annals of Rheumatic Diseases (2022)Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Rizi A, Kremerskothen J, Kiener HP, Müller S, T Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A
LASP1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
Nature Communications (2021)Croft AP, Campos J, Jansen K, Turner J, Marshall J, Attar M, Savary L, Perlman H, Barone F, McGettrick H, Fearon D, Wei K, Raychaudhuri S, Korsunsky I, Brenner M, Coles M, Sansom S, Filer A, Wehmeyer C, Naylor A, Kemble S, Begum J, Dürholz K, Buckley C
Distinct fibroblast subsets drive inflammation and tissue damage in arthritis.
Nature (2019)Wehmeyer C, Frank S, Beckmann D, Korb-Pap A, Cromme C, Böttcher M, Kamradt T, Kramer I, Kneissel M, Stratis A, König U, Fennen M, Held A, Paruzel P, Hartmann C, van den Berg W, Pap T, Dankbar B
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.
Science Translational Medicine (2016)Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich R, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T
Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.
Nature Medicine (2015)To get an overview of all our publications please see our IMM publication list: https://www.medizin.uni-muenster.de/imm/forschung/publikationen.html