Arbeitsgruppe Knochen- und Tumorbiologie

I completed my PhD at the University of Muenster at Prof Pap´s lab where I investigated the impact of fibroblast-like synoviocytes on bone homeostasis in rheumatoid arthritis (RA). I joined the University of Birmingham/UK in 2016 as a Postdoctoral researcher at the Institute of Inflammation and Ageing working with Prof Chris Buckley´s team and was awarded a DFG research fellowship to investigate the role of podoplanin in RA.

Since 2022 I am a group leader of the Bone & Tumor biology group at the Institute of Musculoskeletal Medicine, University of Muenster/Germany. Our research group focus on bone homeostasis in musculoskeletal diseases accompanied with inflammation or metastatic cancer to identify new therapeutic approaches to reverse bone loss. In detail, we are investigating the bone cancer-cell niche exploring the role of osteocyte-, osteoclast- and tumor cell- crosstalk in models of multiple myeloma bone disease and breast cancer metastasis. Moreover, we are interested on the impact of osteocytes and their canalicular network on bone remodeling in RA.

  • Team

    Celina Deiters
    Technische Assistentin
    Abteilung Molekulare Medizin
    Raum: 0.039
    Tel.: +49-251-83-52229
    Fax: +49 251-83-57462
    Email-Kontakt


     

    Deniz Tulumcuoglu
    Doktorandin
    AG Knochen- und Tumorbiologie
    Abteilung Molekulare Medizin
    Raum: 0.054
    Tel.: +49-251-83-44231
    Fax: +49-251-83-57462
     

     

     

    Rosa Al-Qasemi
    Forschungsassistentin
    Abteilung Molekulare Medizin
    Raum: 0.054
    Tel.: +49-251 83-44231
    Fax: +49 251 83-57462
    Email-Kontakt

     

    Dr. rer. nat. Corinna Wehmeyer
    Postdoc
    Abteilung für Molekulare Medizin
    Raum: 0.048/0.049
    Tel.: +49 (0)251 83-52719
    Fax: +49 (0)251 83-57462
    E-Mail-Kontakt

  • Projekte

    Aktuelle Drittmittelprojekte:

    Deutsche Forschungsgemeinschaft (DFG)

    DFG WE 6095/4-1
    Dr. Corinna Wehmeyer
    In der Knochenmatrix eingebettete Osteozyten und ihre regulatorische Funktion bei der Knochenhomölstase während der Rheumatoiden Arthrits
    2021-2024

    IZKF Interdisziplinäres Zentrum für Klinische Forschung Münster
    Dr. Corinna Wehmeyer,
    Impact of osteocyte-cancer cell crosstalk on bone homeostasis in multiple myeloma"
    2023-2025

  • Publikationen

    Relevant publications

    Waltereit-Kracke V, Wehmeyer C, Beckmann D, Werbenko E, Reinhardt J, Geers F, Dienstbier M, Fennen M, Intemann J, Paruzel P, Korb-Pap A, Pap A, Dankbar B
    Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis.
    Annals of Rheumatic Diseases (2022)

    Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Rizi A,  Kremerskothen J, Kiener HP, Müller S, T Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A
    LASP1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
    Nature Communications (2021)

    Croft AP, Campos J, Jansen K, Turner J, Marshall J, Attar M, Savary L, Perlman H, Barone F, McGettrick H, Fearon D, Wei K, Raychaudhuri S, Korsunsky I, Brenner M, Coles M, Sansom S, Filer A, Wehmeyer C, Naylor A, Kemble S, Begum J, Dürholz K, Buckley C
    Distinct fibroblast subsets drive inflammation and tissue damage in arthritis.
    Nature (2019)

    Wehmeyer C, Frank S, Beckmann D, Korb-Pap A, Cromme C, Böttcher M, Kamradt T, Kramer I, Kneissel M, Stratis A, König U, Fennen M, Held A, Paruzel P, Hartmann C, van den Berg W, Pap T, Dankbar B
    Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.
    Science Translational Medicine (2016)

    Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich R, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T
    Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.
    Nature Medicine (2015)

    To get an overview of all our publications please see our IMM publication list: https://www.medizin.uni-muenster.de/imm/forschung/publikationen.html