Institut für Physiologie II
 
Robert-Koch-Str. 27 b
T: 0251 / 83-55336
verena.hofschroeer@uni-muenster.de

Curriculum vitae
I studied biology and molecular biomedicine at the Westfälische Wilhelms-Universität Münster and the Hasselt University (Belgium). My PhD thesis focused on the nanomechanical properties of human endothelial cells with regard to blood-pressure dependent effects. In 2014 I joined Prof. Albrecht Schwab's laboratory to study adhesive tumour cell-cell interaction forces and the regulatory role of ion transporters and pH played therein. To study these effects in a 3D model, I did an internship at the Radboud University Nijmegen (the Netherlands). In 2017 I became ‘Nachwuchsprofessorin’ at the University of Applied Sciences in Münster. Now I decided to be the manager of the Marie Skłodowska Curie Innovative Training Network pHioniC.

Research Projects

  • Publications

    Search on PubMed of the U.S. National Library Of Medicine (NLM)

    2024

    1. Koch A, Hofschröer V, Schwab A. Na+/H+ exchanger NHE1 is active at cell-cell contacts and facilitates cell dissemination during collective migration of melanoma cells. Exp Dermatol. 2024 Jan;33(1):e14983.

    2020

    1. Hofschröer V, Najder K, Rugi M, Bouazzi R, Cozzolino M, Arcangeli A, Panyi G, Schwab A. Ion channels orchestrate pancreatic ductal adenocarcinoma progression and therapy. Front Pharmacol. 2021 Jan 19;11:586599. eCollection 2020.
    2. Lindemann O, Rossaint J, Najder K, Schimmelpfennig S, Hofschröer V, Wälte M, Fels B, Oberleithner H, Zarbock A, Schwab A. Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels. J Mol Med (Berl). 2020 Mar;98(3):349-360.

     

    2019

    1. Keurhorst D, Liashkovich I, Frontzek F, Nitzlaff S, Hofschröer V, Dreier R, Stock C. MMP3 activity rather than cortical stiffness determines NHE1-dependent invasion of melanoma cells. Cell Int. 2019 Nov 9; 19:285. eCollection 2019.

    2018

    1. Olschewski DN, Hofschröer V, Nielsen N, Seidler DG, Schwab A, Stock C. The angiotensin II type 1 receptor antagonist Losartan affects NHE1-dependent melanoma cell behavior. Cell Physiol Biochem. 2018 Mar 16;45(6):2560-2576.

    2017

     

    1. Hofschröer V, Koch KA, Ludwig FT, Friedl P, Oberleithner H, Stock C*, Schwab A*. Extracellular protonation modulates cell-cell interaction mechanics and invasion in human melanoma cells. Sci Rep. 2017 Feb 13;7:42369.
    2. Di Russo J, Luik AL, Yousif L, Budny S, Oberleithner H, Hofschröer V, Klingauf J, van Bavel E, Bakker EN, Hellstrand P, Bhattachariya A, Albinosson S, Pincet F, Hallmann R, Sorokin LM. Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J. 2017 Jan 17;36(2):183-201.

     

    2016

    1. Schulze-Blasum B, Schröter R, Neugebauer U, Hofschröer V, Pavenstädt H, Ciarimboli G, Schlatter E, Edemir B. The kidney-specific expression of genes can be modulated by the extracellular osmolality. FASEB J. 2016 Oct;30(10):3588-3597.

    2015

    1. Lenders M*, Hofschröer V*, Schmitz B, Kasprzak B, Rohlmann A, Missler M, Pavenstädt H, Oberleithner H, Brand SM, Kusche-Vihrog* and Brand E*. Differential response to endothelial epithelial sodium channel inhibition ex vivo correlates with arterial stiffness in humans. J Hypertens 2015 Dec;33(12):2455-6
    2. Jeggle P*, Hofschröer V*, Maase M, Bertog M, Kusche-Vihrog K. Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium. FASEB J. 2015 Aug 31. Pii: fj. 14-259606

    2014

    1. Paar M, Pavenstädt H, Kusche-Vihrog K, Drüppel V, Oberleithner H, Kliche K. Endothelial sodium channels trigger endothelial salt sensitivity with aging. Hypertension. 2014 Aug;64(2):391-6.
    2. Korte S*, Sträter AS*, Drüppel V, Oberleithner H, Jeggle P, Grossmann C, Fobker M, Nofer JR, Brand E, Kusche-Vihrog K. Feedforward activation of endothelial ENaC by high sodium. FASEB J. 2014 May 27. pii: fj.14-250282

    2013

    1. Drüppel V, Kusche-Vihrog K, Grossmann C, Gekle M, Kasprzak B, Brand E, Pavenstädt H, Oberleithner H, Kliche K. Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome. FASEB J. 2013 Sep;27(9):3652-9.

    2012

    1. Peters W, Drüppel V, Kusche-Vihrog K, Schubert C, Oberleithner H. Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442. PLoS One. 2012;7(1):e29972.